ArticleThe Journal of infectious diseases2008
Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 100 citations in OpenAlex.
- Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum.World journal of gastrointestinal oncology · 2024Article
- In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Development of the Neonatal Intestinal Barrier, Microbiome, and Susceptibility to NEC.Microorganisms · 2023Review
- Apical-Out Enteroids as an Innovative Model for Necrotizing Enterocolitis.The Journal of surgical research · 2023Article
- Models of necrotizing enterocolitis.Seminars in perinatology · 2023Review
- Development of a novel definitive scoring system for an enteral feed-only model of necrotizing enterocolitis in piglets.Frontiers in pediatrics · 2023Article
- State-of-the-art review and update ofFrontiers in pediatrics · 2023Review
- The Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers.Frontiers in immunology · 2022Review
- Necrotizing Enterocolitis: Overview on In Vitro Models.International journal of molecular sciences · 2021Review
- Molecular Characterization ofFoods (Basel, Switzerland) · 2020Article
- New directions in necrotizing enterocolitis with early-stage investigators.Pediatric research · 2020Review
- Cell death of intestinal epithelial cells in intestinal diseases.Sheng li xue bao : [Acta physiologica Sinica] · 2020Review
- Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.Shock (Augusta, Ga.) · 2020Review
- Article
- C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium.Cell stress & chaperones · 2020Article
- Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing EnterocolitismSystems · 2019Article
- Caveolin 1 is Associated with Upregulated Claudin 2 in Necrotizing Enterocolitis.Scientific reports · 2019Article
- Effects of artificially introduced Enterococcus faecalis strains in experimental necrotizing enterocolitis.PloS one · 2019Article
- Bacterial isolation from internal organs of rats (Veterinary world · 2019Article
- Rho kinase inhibition maintains intestinal and vascular barrier function by upregulation of occludin in experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Necrotizing enterocolitis (NEC) is an inflammatory intestinal disorder that affects 2%-5% of all premature infants. Enterobacter sakazakii, a common contaminant of milk-based powdered infant formula, has been implicated as a causative agent of sepsis, meningitis, and NEC in newborn infants, with high mortality rates. However, the role played by E. sakazakii in the pathogenesis of NEC is, to date, not known. Here, we demonstrate for the first time that E. sakazakii can induce clinical and histological NEC in newborn rats. E. sakazakii was found to bind to enterocytes in rat pups at the tips of villi and to intestinal epithelial cells (IEC-6) in culture, with no significant invasion. Exposure to E. sakazakii induced apoptosis and increased the production of interleukin-6 in IEC-6 cells and in the animal model. These data suggest that E. sakazakii could be a potential pathogen that induces NEC and triggers intestinal disease by modulating enterocyte intracellular signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.