ArticleMolecular and cellular biochemistry2008
IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Identification of mouse soleus muscle proteins altered in response to changes in gravity loading.Scientific reports · 2023Article
- The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers.Cancers · 2023Review
- Endothelial IQGAP1 regulates leukocyte transmigration by directing the LBRC to the site of diapedesis.The Journal of experimental medicine · 2019Article
- A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1.Scientific reports · 2017Article
- IQGAP1: insights into the function of a molecular puppeteer.Molecular immunology · 2015Review
- IQGAPs choreograph cellular signaling from the membrane to the nucleus.Trends in cell biology · 2015Review
- A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1.Molecular and cellular biochemistry · 2012Article
- Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42.World journal of biological chemistry · 2012Article
- IQGAP1: a regulator of intracellular spacetime relativity.Journal of immunology (Baltimore, Md. : 1950) · 2012Review
- IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.Bioscience reports · 2011Article
- Liver fluke β-tubulin isotype 2 binds albendazole and is thus a probable target of this drug.Parasitology research · 2010Article
- The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A.Molecular and cellular biology · 2010Article
- Interactions of the 67 kDa laminin receptor and its precursor with laminin.Bioscience reports · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
IQGAPs are cytoskeletal scaffolding proteins which link signalling pathways to the reorganisation of actin and microtubules. Human IQGAP1 has four IQ motifs each of which binds to calmodulin. The same region has been implicated in binding to two calmodulin-like proteins, the myosin essential light chain Mlc1sa and the calcium and zinc ion binding protein S100B. Using synthetic peptides corresponding to the four IQ motifs of human IQGAP1, we showed by native gel electrophoresis that only the first IQ motif interacts with Mlc1sa. This IQ motif, and also the fourth, interacts with the budding yeast myosin essential light chain Mlc1p. The first and second IQ motifs interact with S100B in the presence of calcium ions. This clearly establishes that S100B can interact with its targets through IQ motifs in addition to interacting via previously reported sequences. These results are discussed in terms of the function of IQGAP1 and IQ motif recognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.