ArticleBone marrow transplantation2008
Bacteraemia coincides with low citrulline concentrations after high-dose melphalan in autologous HSCT recipients.
Article in Bone marrow transplantation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Supporting the gastrointestinal microenvironment during high-dose chemotherapy and stem cell transplantation by inhibiting IL-1 signaling with anakinra.Scientific reports · 2022Trial
- Citrulline and albumin as biomarkers for gastrointestinal mucositis in recipients of hematopoietic SCT.Bone marrow transplantation · 2013Trial
- Pronounced Reductions in Plasma Citrulline Indicate Severe Intestinal Mucosal Barrier Injury During Induction Therapy for Pediatric Acute Myeloid Leukemia.European journal of haematology · 2026Article
- Mucositis-associated bloodstream infections in adult haematology patients with fever during neutropenia: risk factors and the impact of mucositis severity.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Markers of intestinal mucositis to predict blood stream infections at the onset of fever during treatment for childhood acute leukemia.Leukemia · 2024Article
- Protective Effect of Intestinal Blautia Against Neutropenic Fever in Allogeneic Transplant Recipients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Third-generation cephalosporin resistant gram-negative bacteraemia in patients with haematological malignancy; an 11-year multi-centre retrospective study.Annals of clinical microbiology and antimicrobials · 2022Article
- Article
- Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening.Gut microbes · 2020Article
- Specific gut microbiota changes heralding bloodstream infection and neutropenic fever during intensive chemotherapy.Leukemia · 2020Article
- Novel Biomarker Candidates for Febrile Neutropenia in Hematological Patients Using Nontargeted Metabolomics.Disease markers · 2018Article
- Human small intestine is capable of restoring barrier function after short ischemic periods.World journal of gastroenterology · 2017Article
- Biomarkers and non-invasive tests for gastrointestinal mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Review
- Serum citrulline as a biomarker of gastrointestinal function during hematopoietic cell transplantation in children.Journal of pediatric gastroenterology and nutrition · 2014Article
- Plasma citrulline as a biomarker for enterocyte integrity in pediatric blood and BMT.Bone marrow transplantation · 2014Article
- Incidence of and risk factors for persistent gram-positive bacteraemia and catheter-related thrombosis in haematopoietic stem cell transplantation.Bone marrow transplantation · 2014Article
- Impact of palifermin on intestinal mucositis of HSCT recipients after BEAM.Bone marrow transplantation · 2014Article
- Serum citrulline levels as a marker of enterocyte function in patients after allogeneic hematopoietic stem cells transplantation - a pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Acute intestinal failure in critically ill patients: is plasma citrulline the right marker?Intensive care medicine · 2011Review
- Low serum citrulline concentration correlates with catheter-related bloodstream infections in children with intestinal failure.JPEN. Journal of parenteral and enteral nutrition · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucosal damage to the intestines induced by myeloablative conditioning for allogeneic PBSC transplant (PBSCT) can be determined by the concentration of citrulline, which is a functional marker of small intestinal enterocytes. Low citrulline concentrations in blood coincide with and are a response to severe mucosal barrier injury. We treated 29 patients with high-dose melphalan 200 mg/m(2) (Mel-200) to prepare for an autologous PBSCT and collected plasma samples from each patient starting before the myeloablative regimen and three times per week thereafter until discharge. The baseline citrulline concentration was 27.6 mM+/-4.0 (mean+/-95% confidence interval; CI), and citrulline concentrations declined rapidly thereafter reaching a nadir averaging 6.7 mM+/-2.7, 12 days after starting Mel-200. Citrulline concentrations, only increased gradually and were still low (12 mM+/-4) at discharge. A total of 20 patients developed fever, which was associated with bacteraemia in 10 cases. Their mean citrulline concentrations were lower at 5.5 mM+/-1.5 than were those of patients without bacteraemia (10.2 mM+/-3.9). Importantly, neither the number of preceding neutropenic days nor the mean C-reactive protein (CRP) concentration at the onset of fever was different between these two groups. In conclusion, citrulline concentrations rapidly decline after Mel-200 reflecting intestinal mucosal barrier injury. Low citrulline, rather than the duration of neutropenia, is associated with bacteraemia indicating the importance of an intact mucosal barrier in neutropenic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.