ReviewNature reviews. Drug discovery2008
Creating and evaluating genetic tests predictive of drug response.
Review in Nature reviews. Drug discovery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic Variants Associated With Response to Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer Patients: A Field Synopsis and Meta-Analysis.British journal of biomedical science · 2024Pooled it
- Extrusion 3D Printing of Paracetamol Tablets from a Single Formulation with Tunable Release Profiles Through Control of Tablet Geometry.AAPS PharmSciTech · 2018Article
- Prediction of Drug-Gene Interaction by Using Metapath2vec.Frontiers in genetics · 2018Article
- GLCCI1 rs37973: A potential genetic predictor of therapeutic response to inhaled corticosteroids in Chinese asthma patients.Medicine · 2017Article
- Economic evaluations of personalized medicine: existing challenges and current developments.Pharmacogenomics and personalized medicine · 2015Review
- Is personalized medicine achievable in obstetrics?Seminars in perinatology · 2014Review
- Pharmacogenomics and adverse drug reactions in children.Frontiers in genetics · 2014Review
- A semi-supervised approach to extract pharmacogenomics-specific drug-gene pairs from biomedical literature for personalized medicine.Journal of biomedical informatics · 2013Article
- An iterative searching and ranking algorithm for prioritising pharmacogenomics genes.International journal of computational biology and drug design · 2013Article
- A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text.Journal of biomedical informatics · 2012Article
- The Nuremberg Code subverts human health and safety by requiring animal modeling.BMC medical ethics · 2012Review
- The institutional review board is an impediment to human research: the result is more animal-based research.Philosophy, ethics, and humanities in medicine : PEHM · 2011Article
- Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure.Anti-cancer agents in medicinal chemistry · 2010Review
- Is the use of sentient animals in basic research justifiable?Philosophy, ethics, and humanities in medicine : PEHM · 2010Review
- Development of a Pharmacogenetic Predictive Test in asthma: proof of concept.Pharmacogenetics and genomics · 2010Article
- Improving the prediction of pharmacogenes using text-derived drug-gene relationships.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2010Article
- IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.Nature genetics · 2009Article
- Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Are animal models predictive for humans?Philosophy, ethics, and humanities in medicine : PEHM · 2009Review
- Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity.Expert opinion on drug metabolism & toxicology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
A key goal of pharmacogenetics--the use of genetic variation to elucidate inter-individual variation in drug treatment response--is to aid the development of predictive genetic tests that could maximize drug efficacy and minimize drug toxicity. The completion of the Human Genome Project and the associated HapMap Project, together with advances in technologies for investigating genetic variation, have greatly advanced the potential to develop such tests; however, many challenges remain. With the aim of helping to address some of these challenges, this article discusses the steps that are involved in the development of predictive tests for drug treatment response based on genetic variation, and factors that influence the development and performance of these tests.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.