ArticleJournal of bacteriology2008
Vibrio cholerae VciB promotes iron uptake via ferrous iron transporters.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- A co-conserved gene pair supportsJournal of bacteriology · 2025Article
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- A co-conserved gene pair supportsbioRxiv : the preprint server for biology · 2025Article
- The Bradyrhizobium japonicum fsrB gene is essential for utilization of structurally diverse ferric siderophores to fulfill its nutritional iron requirement.Molecular microbiology · 2023Article
- Vibrio cholerae VciB Mediates Iron Reduction.Journal of bacteriology · 2017Article
- Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
- Nonredundant Roles of Iron Acquisition Systems in Vibrio cholerae.Infection and immunity · 2016Article
- Catechol Siderophore Transport by Vibrio cholerae.Journal of bacteriology · 2015Article
- TonB-dependent heme iron acquisition in the tsetse fly symbiont Sodalis glossinidius.Applied and environmental microbiology · 2015Article
- AhpC is required for optimal production of enterobactin by Escherichia coli.Journal of bacteriology · 2012Article
- The Vibrio cholerae VctPDGC system transports catechol siderophores and a siderophore-free iron ligand.Molecular microbiology · 2011Article
- The fbpABC operon is required for Ton-independent utilization of xenosiderophores by Neisseria gonorrhoeae strain FA19.Infection and immunity · 2011Article
- TonB-dependent transporters and their occurrence in cyanobacteria.BMC biology · 2009Article
- Genetics and virulence association of the Shigella flexneri sit iron transport system.Infection and immunity · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Vibrio cholerae uses a variety of strategies for obtaining iron in its diverse environments. In this study we report the identification of a novel iron utilization protein in V. cholerae, VciB. The vciB gene and its linked gene, vciA, were isolated in a screen for V. cholerae genes that permitted growth of an Escherichia coli siderophore mutant in low-iron medium. The vciAB operon encodes a predicted TonB-dependent outer membrane receptor, VciA, and a putative inner membrane protein, VciB. VciB, but not VciA, was required for growth stimulation of E. coli and Shigella flexneri strains in low-iron medium. Consistent with these findings, TonB was not needed for VciB-mediated growth. No growth enhancement was seen when vciB was expressed in an E. coli or S. flexneri strain defective for the ferrous iron transporter Feo. Supplying the E. coli feo mutant with a plasmid encoding either E. coli or V. cholerae Feo, or the S. flexneri ferrous iron transport system Sit, restored VciB-mediated growth; however, no stimulation was seen when either of the ferric uptake systems V. cholerae Fbp and Haemophilus influenzae Hit was expressed. These data indicate that VciB functions by promoting iron uptake via a ferrous, but not ferric, iron transport system. VciB-dependent iron accumulation via Feo was demonstrated directly in iron transport assays using radiolabeled iron. A V. cholerae vciB mutant did not exhibit any growth defects in either in vitro or in vivo assays, possibly due to the presence of other systems with overlapping functions in this pathogen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.