ArticleNucleic acids research2008
YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Rapid identification of key antibiotic resistance genes iniScience · 2025Article
- Friend or Foe: Protein Inhibitors of DNA Gyrase.Biology · 2024Review
- Article
- Article
- Ter-Seq: A high-throughput method to stabilize transient ternary complexes and measure associated kinetics.Protein science : a publication of the Protein Society · 2023Article
- UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer.Cell death & disease · 2021Article
- TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.Nature communications · 2020Article
- The ATP-dependent chromatin remodelling enzyme Uls1 prevents Topoisomerase II poisoning.Nucleic acids research · 2019Article
- The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.Molecular microbiology · 2019Article
- Topoisomerases as anticancer targets.The Biochemical journal · 2018Review
- Article
- A biophysical model of supercoiling dependent transcription predicts a structural aspect to gene regulation.BMC biophysics · 2015Article
- A genetic screen in Myxococcus xanthus identifies mutants that uncouple outer membrane exchange from a downstream cellular response.Journal of bacteriology · 2014Article
- Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein.Genes & development · 2014Article
- Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyrase.Antimicrobial agents and chemotherapy · 2014Article
- Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance.Nucleic acids research · 2013Article
- Identification of ZapD as a cell division factor that promotes the assembly of FtsZ in Escherichia coli.Journal of bacteriology · 2012Article
- Identification and characterization of two functionally unknown genes involved in butanol tolerance of Clostridium acetobutylicum.PloS one · 2012Article
- Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Applied microbiology and biotechnology · 2011Review
- Group II intron-anchored gene deletion in Clostridium.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We assign a function for a small protein, YacG encoded by Escherichia coli genome. The NMR structure of YacG shows the presence of an unusual zinc-finger motif. YacG was predicted to be a part of DNA gyrase interactome based on protein-protein interaction network. We demonstrate that YacG inhibits all the catalytic activities of DNA gyrase by preventing its DNA binding. Topoisomerase I and IV activities remain unaltered in the presence of YacG and its action appears to be restricted only to DNA gyrase. The inhibition of the enzyme activity is due to the binding of YacG to carboxyl terminal domain of GyrB. Overexpression of YacG results in growth inhibition and alteration in DNA topology due to uncontrolled inhibition of gyrase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.