ArticleBrain research2008
Expression and function of Nkx6.3 in vertebrate hindbrain.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Molecular Organization and Patterning of the Medulla Oblongata in Health and Disease.International journal of molecular sciences · 2022Review
- Deregulated NKL Homeobox Genes in B-Cell Lymphoma.Cancers · 2019Review
- Article
- Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.PLoS genetics · 2015Article
- Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders.The pharmacogenomics journal · 2015Article
- The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas.Physiological reports · 2014Article
- Lhx3-Chx10 reticulospinal neurons in locomotor circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Xenopus Nkx6.1 and Nkx6.2 are required for mid-hindbrain boundary development.Development genes and evolution · 2013Article
- Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.Nature genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Homeodomain transcription factors serve important functions in organogenesis and tissue differentiation, particularly with respect to the positional identity of individual cells. The Nkx6 subfamily controls tissue differentiation in the developing central nervous system where they function as transcriptional repressor proteins. Recent work indicates that Nkx6.3 is expressed in hindbrain V2 interneurons that co-express Nkx6.1, suggesting the possibility of functional redundancy. Here, we report that Nkx6.3 expression is specific to Chx10+ V2a interneurons but not to Gata3+ V2b interneurons of the hindbrain, and that Nkx6.3 expression appears to mark cells of the prospective medullary reticular formation. Molecular analysis of Nkx6.3 null embryonic mouse hindbrain did not reveal detectable defects in progenitor markers, motor neuron or V2 interneuron sub-types. Forced expression of Nkx6.3 and Nkx6.1 promote V2 interneuron differentiation in the developing chick hindbrain. These findings indicate Nkx6.3 function is dispensable for CNS development and lead to the proposal that absence of overt defects is due to functional compensation from a related homeodomain transcription factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.