ArticleBrain research2008
Microinjection of muscimol into the dorsomedial hypothalamus suppresses MDMA-evoked sympathetic and behavioral responses.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- A synergistic effect of herb and acupuncture on the methamphetamine.Integrative medicine research · 2024Article
- Leptin signaling and its central role in energy homeostasis.Frontiers in neuroscience · 2023Review
- Multifaceted roles of orexin neurons in mediating methamphetamine-induced changes in body temperature and heart rate.IBRO neuroscience reports · 2022Article
- GABAergic function in the lateral hypothalamus regulates feeding behavior: Possible mediation via orexin.Neuropsychopharmacology reports · 2019Article
- The Dorsomedial Hypothalamus Is Involved in the Mediation of Autonomic and Neuroendocrine Responses to Restraint Stress.Frontiers in pharmacology · 2019Article
- Stereotaxic surgery for implantation of guide cannulas for microinjection into the dorsomedial hypothalamus in young rats.MethodsX · 2019Article
- Hypothalamic or Extrahypothalamic Modulation and Targeted Temperature Management After Brain Injury.Therapeutic hypothermia and temperature management · 2017Review
- Article
- Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus.Brain research · 2015Article
- Protracted effects of chronic stress on serotonin-dependent thermoregulation.Stress (Amsterdam, Netherlands) · 2015Article
- Article
- Meth math: modeling temperature responses to methamphetamine.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment.Pharmacology research & perspectives · 2014Article
- Independent of 5-HT1A receptors, neurons in the paraventricular hypothalamus mediate ACTH responses from MDMA.Neuroscience letters · 2013Article
- The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress.Physiology & behavior · 2012Article
- The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.Neuroscience letters · 2011Article
- Balanced excitation and inhibition in temperature responses to meth.Temperature (Austin, Tex.)Article
- The Ergogenic Effect of Amphetamine.Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
When given systemically to rats and humans, the drug of abuse 3,4 methylenedioxymethamphetamine (ecstasy, MDMA) elicits hyperthermia, hyperactivity, tachycardia, and hypertension. Chemically stimulating the dorsomedial hypothalamus (DMH), a brain region known to be involved in thermoregulation and in stress responses, causes similar effects. We therefore tested the hypothesis that neuronal activity in the DMH plays a role in MDMA-evoked sympathetic and behavioral responses by microinjecting artificial CSF or muscimol, a neuronal inhibitor, into the DMH prior to intravenous infusion of saline or MDMA in conscious rats. Core temperature, heart rate, mean arterial pressure and locomotor activity were recorded by telemetry every minute for 120 min. In rats previously microinjected with CSF, MDMA elicited significant increases from baseline in core temperature (+1.3+/-0.3 degrees C), locomotion (+50+/-6 counts/min), heart rate (+142+/-16 beats/min), and mean arterial pressure (+26+/-3 mmHg). Microinjecting muscimol into the DMH prior to MDMA prevented increases in core temperature and locomotion and attenuated increases in heart rate and mean arterial pressure. These results indicate that neuronal activity in the DMH is necessary for the sympathetic and behavioral responses evoked by MDMA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.