SynthesisDrug and alcohol dependence2008
Meta-analysis of depression and substance use and impairment among cocaine users.
Synthesis in Drug and alcohol dependence, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02420561 (Motivational Interviewing to Reduce Substance Use Among Depression Patients), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Motivational Interviewing to Reduce Substance Use Among Depression Patients
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Psychosocial interventions for stimulant use disorder.The Cochrane database of systematic reviews · 2024Pooled it
- Meta-analysis of depression and substance use among individuals with alcohol use disorders.Journal of substance abuse treatment · 2009Pooled it
- Quality-of-life improvements associated with reductions in cocaine-positive urine drug screens.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Trial
- Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms.Journal of clinical psychopharmacology · 2014Trial
- The moderating effects of group cognitive-behavioral therapy for depression among substance users.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2012Trial
- The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression.The American journal of drug and alcohol abuse · 2012Trial
- Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms.Addiction (Abingdon, England) · 2012Trial
- Relationship between depression on cocaine craving over time amongst patients in a trial evaluating the use of buprenorphine on cocaine use.Drug and alcohol dependence reports · 2026Article
- Linking Affective Symptoms and Brain Morphology in Cocaine Use Disorder: An Integrated Network Approach.European addiction research · 2026Article
- Major Depression in Comorbidity with Substance use Disorders: Patients' Features and Clinical-Neurobiological Rationale of Antidepressant Treatments.Current neuropharmacology · 2025Review
- The Effect of Transcranial Direct Current Stimulation (tDCS) on Cocaine Addiction: A Narrative Review.Journal of clinical medicine · 2023Review
- Prevalence of Depressive Symptoms Among an Undergraduate Health Sciences Student Population: A Cross-Sectional Study.Cureus · 2023Article
- Article
- Temporal association of pre-pandemic perceived social support with psychological resilience and mental well-being during the COVID-19 pandemic among people with a history of injection drug use.Drug and alcohol dependence · 2023Article
- A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review.Nutrients · 2022Review
- Associations of substance abuse histories and gambling addiction history with post-traumatic stress symptoms and depressive symptoms among Chinese prisoners.European journal of psychotraumatology · 2021Article
- Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users.Frontiers in psychiatry · 2021Article
- Short and long-term improvements in psychiatric symptomatology to validate clinically meaningful treatment outcomes for cocaine use disorders.Drug and alcohol dependence · 2019Article
- Using a data science approach to predict cocaine use frequency from depressive symptoms.Drug and alcohol dependence · 2019Article
- Psychosocial interventions for psychostimulant misuse.The Cochrane database of systematic reviews · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe study evaluated, among cocaine users, the hypothesized positive association of depression and concurrent cocaine use and impairment, alcohol use and impairment, and general drug use and impairment. The hypothesis that gender would moderate these associations, with women showing a stronger correlation between depression and measures of substance use and impairment, was also tested. Also examined was the association of depression with future cocaine use and impairment and substance use treatment participation.
methodsEmpirical reports on adult cocaine users published in English in peer-reviewed journals since 1986 that contained data on depression and substance use outcome(s) were obtained using a systematic search. Studies that placed restrictions on range of depression scores to select the sample, experiments that administered cocaine to subjects, and trials of antidepressant medications were excluded. The search yielded 60 studies for the analysis including 53 reports that collected data from clinical venues and seven that were community-based.
resultsAs hypothesized, the analyses showed that depression is associated with concurrent cocaine-, alcohol-, and general drug use and impairment. Effect sizes were small. Hypothesized moderating effects of gender were not supported. Depression was not associated, at a statistically significant level, with treatment participation or future cocaine use and impairment.
conclusionsDepression is consistently but modestly associated with measures of cocaine-, alcohol-, and general drug use and impairment among cocaine users. Associations of depression with treatment participation and with future cocaine use and impairment are not immediately evident, although limitations of data warrant cautious interpretation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.