ArticleDevelopmental biology2008
Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Ribbon constrains dendritic pruning via actin scaffolding and exocyst complex.Cellular & molecular biology letters · 2026Article
- The Lolal-dpp axis mediates the regulation of host reproduction by gut symbionts in insects.Nature communications · 2026Article
- Arc controls organ architecture through modulation of Crb and MyoII.The Journal of cell biology · 2025Article
- Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.iScience · 2023Article
- DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord.Biological research · 2023Article
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.The Journal of cell biology · 2022Article
- Forced into shape: Mechanical forces in Drosophila development and homeostasis.Seminars in cell & developmental biology · 2021Review
- Secrets of secretion-How studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function.Current topics in developmental biology · 2021Article
- Transcriptomic and Genetic Analyses Identify the Krüppel-Like Factor Dar1 as a New Regulator of Tube-Shaped Long Tendon Development.Frontiers in cell and developmental biology · 2021Article
- Multiple Requirements for Rab GTPases in the Development ofG3 (Bethesda, Md.) · 2020Article
- Rho-Kinase Planar Polarization at Tissue Boundaries Depends on Phospho-regulation of Membrane Residence Time.Developmental cell · 2020Article
- Review
- Article
- An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity.PLoS genetics · 2018Article
- Sex-biased gene expression and sequence conservation in Atlantic and Pacific salmon lice (Lepeophtheirus salmonis).BMC genomics · 2016Article
- Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors.PloS one · 2016Article
- Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression.Developmental biology · 2016Article
- The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC.Development (Cambridge, England) · 2015Article
- Cargo sorting in the endocytic pathway: a key regulator of cell polarity and tissue dynamics.Cold Spring Harbor perspectives in biology · 2014Review
- Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation.Development (Cambridge, England) · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although the formation and maintenance of epithelial tubes are essential for the viability of multicellular organisms, our understanding of the molecular and cellular events coordinating tubulogenesis is relatively limited. Here, we focus on the activities of Ribbon, a novel BTB-domain containing nuclear protein, in the elongation of two epithelial tubes: the Drosophila salivary gland and trachea. We show that Ribbon interacts with Lola Like, another BTB-domain containing protein required for robust nuclear localization of Ribbon, to upregulate crumbs expression and downregulate Moesin activity. Our ultrastructural analysis of ribbon null salivary glands by TEM reveals a diminished pool of subapical vesicles and an increase in microvillar structure, cellular changes consistent with the known role of Crumbs in apical membrane generation and of Moesin in the cross-linking of the apical membrane to the subapical cytoskeleton. Furthermore, the subapical localization of Rab11, a small GTPase associated with apical membrane delivery and rearrangement, is significantly diminished in ribbon mutant salivary glands and tracheae. These findings suggest that Ribbon and Lola Like function as a novel transcriptional cassette coordinating molecular changes at the apical membrane of epithelial cells to facilitate tube elongation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.