ArticleCell2008
A lexicon for homeodomain-DNA recognition.
Article in Cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- HOX gene dysregulation in head and neck squamous cell carcinoma: mechanisms, clinical relevance, and future perspectives.Frontiers in oncology · 2026Review
- Cancer-Targeting Applications of Cell-Penetrating Peptides.International journal of molecular sciences · 2024Review
- Multimodal Hox5 activity generates motor neuron diversity.Communications biology · 2024Article
- Typical Enhancers, Super-Enhancers, and Cancers.Cancers · 2022Review
- Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities.Nature communications · 2022Article
- The power of the (imperfect) palindrome: Sequence-specific roles of palindromic motifs in gene regulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Review
- Differential abilities to engage inaccessible chromatin diversify vertebrate Hox binding patterns.Development (Cambridge, England) · 2020Article
- Article
- Control of tissue morphogenesis by the HOX geneDevelopment (Cambridge, England) · 2020Article
- The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila.Developmental biology · 2019Article
- Homeodomain proteins: an update.Chromosoma · 2016Review
- Genomic sequencing of a dyslexia susceptibility haplotype encompassing ROBO1.Journal of neurodevelopmental disorders · 2016Article
- Hox regulation of transcription: more complex(es).Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding.PLoS genetics · 2012Article
- SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.The Journal of clinical investigation · 2012Article
- Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development.Nucleic acids research · 2012Article
- High-throughput mapping of the promoters of the mouse olfactory receptor genes reveals a new type of mammalian promoter and provides insight into olfactory receptor gene regulation.Genome research · 2011Article
- Systematic characterization of protein-DNA interactions.Cellular and molecular life sciences : CMLS · 2011Review
- Comparing anterior and posterior Hox complex formation reveals guidelines for predicting cis-regulatory elements.Developmental biology · 2010Article
- Deciphering the genome's regulatory code: the many languages of DNA.BioEssays : news and reviews in molecular, cellular and developmental biology · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Decoding the cis-regulatory logic of eukaryotic genomes requires knowledge of the DNA-binding specificities of all transcription factors. New work (Berger et al., 2008; Noyes et al., 2008) provides individual specificities for nearly all Drosophila and mouse homeodomains, key DNA-binding domains in many transcription factors. The data underscore the complexity of determining target specificities in vivo.
Indexed as
Identifiers
18585344What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.