ReviewParkinsonism & related disorders2008
Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
Review in Parkinsonism & related disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.Neuroscience and biobehavioral reviews · 2026Review
- Changes in Cerebellar Multiunit Activity Associated with Ventrolateral Striatal Injury During Spontaneous Motor Behavior.Medical sciences (Basel, Switzerland) · 2026Article
- Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease - a prospective to APurinergic signalling · 2024Article
- The adenosine-APurinergic signalling · 2023Article
- Reversal of haloperidol-induced orofacial dyskinesia and neuroinflammation by isoflavones.Molecular biology reports · 2022Article
- Effects of CATECHIN on reserpine-induced vacuous chewing movements: behavioral and biochemical analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and ΔBritish journal of pharmacology · 2020Article
- The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation.Pharmacological reviews · 2018Review
- Crocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism.Iranian journal of basic medical sciences · 2016Article
- Alteration of Cytokines Levels in the Striatum of Rats: Possible Participation in Vacuous Chewing Movements Induced by Antipsycotics.Neurochemical research · 2016Article
- Harpagophytum Procumbens Ethyl Acetate Fraction Reduces Fluphenazine-Induced Vacuous Chewing Movements and Oxidative Stress in Rat Brain.Neurochemical research · 2016Article
- Behavioral and neurochemical effects induced by reserpine in mice.Psychopharmacology · 2016Article
- Subthalamic and Cortical Local Field Potentials Associated with Pilocarpine-Induced Oral Tremor in the Rat.Frontiers in behavioral neuroscience · 2016Article
- Neurochemical measurement of adenosine in discrete brain regions of five strains of inbred mice.PloS one · 2014Article
- Bauhinia forficata prevents vacuous chewing movements induced by haloperidol in rats and has antioxidant potential in vitro.Neurochemical research · 2013Article
- Article
- The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond.Journal of the experimental analysis of behavior · 2012Review
- Xanthines as adenosine receptor antagonists.Handbook of experimental pharmacology · 2011Review
- Pharmacological and physiological characterization of the tremulous jaw movement model of parkinsonian tremor: potential insights into the pathophysiology of tremor.Frontiers in systems neuroscience · 2011Article
- Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism.Neuroscience · 2010Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
Abstract
Adenosine A(2A) antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A(2A) antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated rats, but there were no effects of infusions into the accumbens shell or ventrolateral neostriatum. In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.