ArticleJournal of clinical immunology2008
Increased granulysin expression in peripheral blood cells of patients with primary biliary cirrhosis and its clinical implications.
Article in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Topical clobetasol for the treatment of toxic epidermal necrolysis: study protocol for a randomized controlled trial.Trials · 2015Trial
- Gene expression profiles of peripheral blood mononuclear cells in primary biliary cirrhosis.Clinical and experimental medicine · 2014Article
- Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.Blood · 2010Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGranulysin is a cytotoxic molecule involved in cellular immune reactions. MATERIALS AND
methodsThe levels of granulysin mRNA in the peripheral blood and serum granulysin of patients with primary biliary cirrhosis (PBC) were determined by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The expression of granulysin mRNA and serum protein in PBC was increased compared to the controls.
resultsThe expression of granulysin mRNA or serum protein showed close associations, respectively, with natural killer cell population in PBC patients. Serum granulysin was down-regulated by steroid and ursodeoxycholic therapy for PBC according to the improvement of severity of PBC. In addition, the expression of serum granulysin were related to serum total bilirubin and Mayo Clinic risk score. The serum granulysin reflected the cellular immune status of patients with PBC, and the expression correlated with the severity of PBC.
conclusionTherefore, there is a clinical benefit to monitoring granulysin as a biomarker of the prognosis of patients with PBC.
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