ArticleMolecular biology reports2009
Molecular cloning and expression profile analysis of a novel mouse testis-specific expression gene mtIQ1.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- IQ motif family genes in male infertility: pathogenesis, mechanisms, and clinical perspectives.Frontiers in reproductive health · 2025Review
- Article
- Molecular characterization of a KIF3A-like kinesin gene in the testis of the Chinese fire-bellied newt Cynops orientalis.Molecular biology reports · 2012Article
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Authors and funding
3 authors.
Funding
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Abstract
A novel testis-specific gene termed mtIQ1 (GenBank Accession No. DQ153246) was identified by digital differential display. Sequence analysis revealed that mtIQ1 protein is a new member of calmodulin (CaM) binding protein families with conserved Ile and Gln residues (IQ motif). RT-PCR and Northern blot analysis revealed that a 0.9 kb mtIQ1 transcript was only expressed in adult mouse testis and not expressed in nine other tissues. The expression of mtIQ1 mRNA was developmentally upregulated in the testes during sexual maturation and was, conversely, downregulated by experimental cryptorchidism in vivo. The green fluorescence produced by pEGFP-C3/mtIQ1 was detected mainly in the nucleus of GC-1 cells 24 h post-transfection. Results of in situ hybridization assay confirmed that mtIQ1 was expressed in seminiferous tubules, more precisely in spermatocytes. The testis-specific and time-dependent expression pattern of mtIQ1 in postnatal mouse testes suggested that it might be involved in the regulation of spermatogenesis and sperm maturation.
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Registered trials
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