ReviewInternational urology and nephrology2008
Renal senescence in 2008: progress and challenges.
Review in International urology and nephrology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 84 citations in OpenAlex.
- Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids.Age (Dordrecht, Netherlands) · 2012Trial
- Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease.Renal failure · 2025Review
- Renal aging and its consequences: navigating the challenges of an aging population.Frontiers in pharmacology · 2025Review
- The Impairment of Endothelial Autophagy Accelerates Renal Senescence by Ferroptosis and NLRP3 Inflammasome Signaling Pathways with the Disruption of Endothelial Barrier.Antioxidants (Basel, Switzerland) · 2024Article
- Protectin DX as a therapeutic strategy against frailty in mice.GeroScience · 2023Article
- RAGE is a critical factor of sex-based differences in age-induced kidney damage.Frontiers in physiology · 2023Article
- Using random forest algorithm for glomerular and tubular injury diagnosis.Frontiers in medicine · 2022Article
- Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging.International journal of molecular sciences · 2021Review
- Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds.International journal of environmental research and public health · 2021Review
- Identification of an Altered Matrix Signature in Kidney Aging and Disease.Journal of the American Society of Nephrology : JASN · 2021Article
- Caloric restriction inhibits renal artery ageing by reducing endothelin-1 expression.Annals of translational medicine · 2021Article
- Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases.Frontiers in physiology · 2021Review
- Early detection of chronic renal disease: coordinated work between primary and specialized care in an ambulatory renal network of Peru.Jornal brasileiro de nefrologia · 2019Article
- Role of Aldosterone and Mineralocorticoid Receptor in Cardiovascular Aging.Frontiers in endocrinology · 2019Review
- Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly.Pharmacology & therapeutics · 2019Review
- Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence.The Korean journal of internal medicine · 2017Article
- Association Between IL-18 and Carotid Intima-Media Thickness in Patients with Type II Diabetic Nephropathy.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- The Expression Changes of Inflammasomes in the Aging Rat Kidneys.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Association of relative telomere length with progression of chronic kidney disease in two cohorts: effect modification by smoking and diabetes.Scientific reports · 2015Article
- Fibrosis and renal aging.Kidney international supplements · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and serious fluid and electrolyte imbalance. While the entire mystery of aging is far from being clear, the role of oxidative stress, telomere length, Klotho gene expression, and the renin angiotensin system seem to be the key mechanisms involved in aging. Aging, being a complex process, involves an array of intertwined molecular pathways. Simultaneous study of multiple molecular pathways in parallel could provide invaluable information in understanding the clinical course of kidney aging and elucidating mechanisms that play key roles in the aging process. A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.