ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2008
Immune response to the 7-valent pneumococcal conjugate vaccine in 30 asplenic children.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Pneumococcal serotype-specific IgG and opsonophagocytic activity in young Japanese patients with asplenia.Human vaccines & immunotherapeutics · 2021Article
- Article
- Pneumococcal vaccination and efficacy in patients with heterotaxy syndrome.Pediatric research · 2017Article
- Is it worth investigating splenic function in patients with celiac disease?World journal of gastroenterology · 2013Review
- Heterotaxy syndrome: defining contemporary disease trends.Pediatric cardiology · 2010Article
- Pneumococcal and influenza immunization in asplenic persons: a retrospective population-based cohort study 1990-2002.BMC infectious diseases · 2010Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to determine the concentration of pneumococcal antibodies after a dose of 7-valent pneumococcal conjugate vaccine (PCV7) in 30 asplenic children between 4 months and 19 years of age. Fifteen children had received pneumococcal polysaccharide vaccine (PPV) approximately 5 years prior to vaccination with PCV7. The antibody concentrations against serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F were measured by ELISA before and after the PCV7 vaccination. Before vaccination with PCV7, the antibody concentrations were similar in children who had or had not received PPV previously. A dose of PCV7 stimulated a good immune response in asplenic patients. Prior immunization with PPV did not affect the antibody concentration after the vaccination with PCV7. In conclusion, asplenic children vaccinated with PPV may need revaccination with PPV earlier than the recommended 3-5 years after the first dose. PCV7 induces a satisfactory immune response in asplenic patients and should be considered as an alternative vaccine in that patient group.
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