ReviewEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2008
Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies.
Review in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Progression of radial tears in L5-S1 intervertebral disc depends on location and type of movements: An in-silico study.PloS one · 2026Article
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- A suture technique combining annulus fibrosis with posterior longitudinal ligament for lumbar disc herniation under endoscopy.Journal of orthopaedics · 2025Article
- [Sport after disc herniation].Orthopadie (Heidelberg, Germany) · 2024Review
- Clinical effect of full endoscopic lumbar annulus fibrosus suture.Journal of orthopaedic surgery and research · 2024Article
- Radiologic Analysis of Causes of Early Recurrence After Percutaneous Endoscopic Transforaminal Discectomy.Global spine journal · 2024Article
- Review
- Article
- Lumbar Intervertebral Disc Herniation: Annular Closure Devices and Key Design Requirements.Bioengineering (Basel, Switzerland) · 2022Review
- Ossification and Fusion of the Vertebral Ring Apophysis as an Important Part of Spinal Maturation.Journal of clinical medicine · 2021Article
- A comprehensive tool box for large animal studies of intervertebral disc degeneration.JOR spine · 2021Article
- Animal models of regenerative medicine for biological treatment approaches of degenerative disc diseases.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Article
- Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C.Journal of cellular and molecular medicine · 2020Article
- Article
- Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model.JOR spine · 2020Article
- FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration.Frontiers in cell and developmental biology · 2020Article
- Calcium Phosphate Cement Causes Nucleus Pulposus Cell Degeneration through the ERK Signaling Pathway.Open life sciences · 2020Article
- Stem cell therapy in discogenic back pain.Journal of spine surgery (Hong Kong) · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to assess the impact of a landmark annular lesion model on our understanding of the etiopathogenesis of IVD degeneration and to appraise current IVD repairative strategies. A number of studies have utilised the Osti sheep model since its development in 1990. The experimental questions posed at that time are covered in this review, as are significant recent advances in annular repair strategies. The ovine model has provided important spatial and temporal insights into the longitudinal development of annular lesions and how they impact on other discal and paradiscal components such as the NP, cartilaginous end plates, zygapophyseal joints and vertebral bone and blood vessels. Important recent advances have been made in biomatrix design for IVD repair and in the oriented and dynamic culture of annular fibrochondrocytes into planar, spatially relevant, annular type structures. The development of hyaluronan hydrogels capable of rapid in situ gelation offer the possibility of supplementation of matrices with cells and other biomimetics and represent a significant advance in biopolymer design. New generation biological glues and self-curing acrylic formulations which may be augmented with slow delivery biomimetics in microcarriers may also find application in the non-surgical repair of annular defects. Despite major advances, significant technical challenges still have to be overcome before the biological repair of this intractable connective tissue becomes a realistic alternative to conventional surgical intervention for the treatment of chronic degenerate IVDs.
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