ArticlePediatric nephrology (Berlin, Germany)2008
Long-term results of rhGH treatment in children with renal failure: experience of the French Society of Pediatric Nephrology.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease.Nature reviews. Nephrology · 2019Guideline
- The potential effects of anabolic-androgenic steroids and growth hormone as commonly used sport supplements on the kidney: a systematic review.BMC nephrology · 2019Pooled it
- Growth hormone for children with chronic kidney disease.The Cochrane database of systematic reviews · 2012Pooled it
- The kidney and IGF-1 axis as a central regulator of linear growth and adult height in pediatric health and disease.Childhood kidney diseases · 2026Review
- Growth and Recombinant Human Growth Hormone Use in Children with Congenital Chronic Kidney Disease: A Multicentric Contemporary Study.Hormone research in paediatrics · 2026Article
- Long-Term Outcomes of Kidney Transplantation in Children.Pediatric clinics of North America · 2019Review
- Clinical and genetic analysis of distal renal tubular acidosis in three Chinese children.Renal failure · 2018Article
- Growth hormone treatment improves final height and nutritional status of children with chronic kidney disease and growth deceleration.Journal of endocrinological investigation · 2018Article
- Near-adult height in male kidney transplant recipients started on growth hormone treatment in late puberty.Pediatric nephrology (Berlin, Germany) · 2018Article
- Growth hormone therapy in children with CKD after more than two decades of practice.Pediatric nephrology (Berlin, Germany) · 2016Review
- Growth hormone therapy in children with chronic renal failure.The Eurasian journal of medicine · 2015Review
- Growth in children with chronic kidney disease: 13 years follow up study.Journal of nephrology · 2014Article
- Nutritional management and growth in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- The consequences of chronic kidney disease on bone metabolism and growth in children.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Review
- Effectiveness of rhGH treatment on final height of renal-transplant recipients in childhood.Pediatric nephrology (Berlin, Germany) · 2012Article
- Nutrition and growth in children with chronic kidney disease.Nature reviews. Nephrology · 2011Review
- Optimal hemodialysis prescription: do children need more than a urea dialysis dose?International journal of nephrology · 2011Article
- Etiology and treatment of growth retardation in children with chronic kidney disease and end-stage renal disease: a historical perspective.Pediatric nephrology (Berlin, Germany) · 2010Review
- The effect of rhGH on height velocity and BMI in children with CKD: a report of the NAPRTCS registry.Pediatric nephrology (Berlin, Germany) · 2009Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few publications have described the long-term effects of recombinant human growth hormone (rhGH) in uremic patients. This study reports the results of rhGH therapy at the end of treatment and at adult age in 178 French patients. At enrollment, 63 patients were under conservative treatment (CT), 40 under hemodialysis (HD), and 75 had a functioning renal transplant (RT). Under rhGH treatment, height velocities (HV) significantly increased in all patients, but the effect was significantly better in the CT group. The HV gain (HV under rhGH-HV before treatment) was similar in all three groups. Increases in HV allowed height standard deviation scores (SDS) catch up, and this effect persisted over a 5-year period. SDS height at the completion of treatment was significantly related to group (best in CT) and response to treatment during the first year. Data on adult height was available for 102 patients. Mean adult height was 162.2 cm in men and 152.9 cm in women, and 46% were > -2 SDS for height. Adult height SDS was correlated with height SDS and spontaneous HV before treatment and effect of treatment. Analysis of adult height in the 49 patients who entered the protocol with a height SDS between -2 and -3 (the current recommendation for rhGH use) revealed that 65% had an adult-height SDS >-2. These adult heights were significantly better if compared with historical cohorts of patients not treated by rhGH; rhGH significantly improves the adult-height prognosis of uremic patients suffering from growth retardation. Early rhGH administration during CT gives better height SDS at both the end of rhGH therapy and in adulthood.
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