ArticleInternational journal of legal medicine2009
Prevalence of adverse drug combinations in a large post-mortem toxicology database.
Article in International journal of legal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Assessment of co-ingestion effects on poisoning patterns, drug-drug interactions, and adverse outcomes in acute toxic exposure.Toxicology reports · 2024Article
- Completed suicides of citalopram users-the role of CYP genotypes and adverse drug interactions.International journal of legal medicine · 2019Article
- A limited number of prescribed drugs account for the great majority of drug-drug interactions.European journal of clinical pharmacology · 2014Article
- Drug concentrations in post-mortem femoral blood compared with therapeutic concentrations in plasma.Drug testing and analysis · 2014Article
- ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram.International journal of legal medicine · 2013Article
- Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning.European journal of clinical pharmacology · 2012Article
- Fatal venlafaxine poisonings are associated with a high prevalence of drug interactions.International journal of legal medicine · 2011Article
- Post-mortem ABCB1 genotyping reveals an elevated toxicity for female digoxin users.International journal of legal medicine · 2011Article
- Adverse interaction of warfarin and paracetamol: evidence from a post-mortem study.European journal of clinical pharmacology · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of important adverse drug combinations was studied among the 37,367 cases included in the Finnish post-mortem toxicology database during 2000-2006. The new SFINX interaction database (Swedish, Finnish, INteraction X-referencing) was utilised to identify adverse drug combinations. Consequently, the 24 drugs chosen for the study generated 96 two-compound combinations possessing potentially severe interactions. The total number of hits for the combinations found in the post-mortem database was 267, which accounts for approximately 0.71% of all cases. The potential role of adverse drug interaction (ADI) in these cases was evaluated from the background information and death certificate. The possible ADI cases comprised 23% of all hits and 0.17% of all cases analysed. In cases with a pharmacodynamic mechanism, the most prominent combinations were medicines causing serotonin syndrome or a beta(1)-blocker with verapamil or diltiazem. In cases with a pharmacokinetic mechanism, half of the cases involved digoxin in combination with verapamil. In one third of the possible ADI cases, a forensic pathologist had noted the studied compounds as an underlying or contributing cause of death, although the agents' specific role in ADIs was rarely recognised.
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