ArticleImmunogenetics2008
Diversity and evolutionary history of the MHC DQA gene in leporids.
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland.Immunogenetics · 2024Article
- Hybridization with mountain hares increases the functional allelic repertoire in brown hares.Scientific reports · 2021Article
- Genetic Diversity ofAnimals : an open access journal from MDPI · 2019Article
- Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds.Parasites & vectors · 2019Article
- Evolution of CCL16 in Glires (Rodentia and Lagomorpha) shows an unusual random pseudogenization pattern.BMC evolutionary biology · 2019Article
- Signatures of historical selection on MHC reveal different selection patterns in the moor frog (Rana arvalis).Immunogenetics · 2018Article
- Article
- Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain.Immunogenetics · 2016Article
- An overview of the lagomorph immune system and its genetic diversity.Immunogenetics · 2016Review
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
- Neofunctionalization of the Sec1 α1,2fucosyltransferase paralogue in leporids contributes to glycan polymorphism and resistance to rabbit hemorrhagic disease virus.PLoS pathogens · 2015Article
- Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus.Immunogenetics · 2014Article
- Article
- Domestication does not narrow MHC diversity in Sus scrofa.Immunogenetics · 2013Article
- Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review.Veterinary research · 2012Review
- Histo-blood group antigens act as attachment factors of rabbit hemorrhagic disease virus infection in a virus strain-dependent manner.PLoS pathogens · 2011Article
- Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.Immunogenetics · 2011Review
- Evolutionary history of an MHC gene in two leporid species: characterisation of Mhc-DQA in the European brown hare and comparison with the European rabbit.Immunogenetics · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The European rabbit (Oryctolagus cuniculus) is used as a model for many human diseases, yet comparatively little is known of its genetics, particularly at important loci such as the major histocompatibility complex (MHC). This study investigated genetic diversity and evolutionary history of the DQA gene in a range of leporid species by analysing coding sequence diversity of exon 2 and intron 2 in 53 individuals of 16 different species. Fifty leporid DQA alleles were detected, including 13 novel European rabbit alleles. In the rabbit, the highest levels of diversity were observed in wild rabbits from Portugal, with wild rabbits from England and domestic rabbits showing less diversity. Within the sample, several recombination events were detected and trans-specific evolution of alleles was evidenced, both being general characteristics of mammalian MHC genes. Positive selection is implicated as operating on six codons within exon 2, which are also subject to positive selection in other mammals. Some of these positions are putative antigen recognition sites and underline the importance of pathogen-driven selection on these MHC genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.