ArticleLab on a chip2008
A practical guide to the staggered herringbone mixer.
Article in Lab on a chip, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
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- Acoustic Rising Microbubbles for Efficient Liquid Operations.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- A 3D ColMA-Based Tenogenic Microenvironment Unveils the Behavior of Tendon Stem/Progenitor Cells (TSPCs) from Tendinopathic Surgical Explants.Bioengineering (Basel, Switzerland) · 2025Article
- Emerging Approaches for the Discovery of Lipid-Based RNA Delivery Systems.Pharmaceutics · 2025Review
- Microfluidic Assembly of Poly(glutamic acid) Nanogels Through SPAAC Click Chemistry.Pharmaceutics · 2025Article
- Optimization of PLGA Nanoparticle Formulation via Microfluidic and Batch Nanoprecipitation Techniques.Micromachines · 2025Article
- Nanogels: Recent Advances in Synthesis and Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2024Review
- Microfluidic Platform with Precisely Controlled Hydrodynamic Parameters and Integrated Features for Generation of Microvortices to Accurately Form and Monitor Biofilms in Flow.ACS biomaterials science & engineering · 2024Article
- Empirical and Computational Evaluation of Hemolysis in a Microfluidic Extracorporeal Membrane Oxygenator Prototype.Micromachines · 2024Article
- Design and Development of Ophthalmic Liposomes from the QbD Perspective.Current pharmaceutical design · 2024Review
- Looking for future biological control agents: the comparative function of the deutosternal groove in mesostigmatid mites.Experimental & applied acarology · 2023Review
- Droplet-Based Microfluidics as a Platform to Design Food-Grade Delivery Systems Based on the Entrapped Compound Type.Foods (Basel, Switzerland) · 2023Review
- Article
- Herringbone micromixers for particle filtration.Biomicrofluidics · 2023Article
- Pre-equilibrium biosensors as an approach towards rapid and continuous molecular measurements.Nature communications · 2022Article
- Serpentine Micromixers Using Extensional Mixing Elements.Micromachines · 2022Article
- Volumetric Scalability of Microfluidic and Semi-Batch Silk Nanoprecipitation Methods.Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
An analytical model of mixing in the staggered herringbone mixer (SHM) was derived to estimate mixing parameters and provide practical expressions to guide mixer design and operation for a wide range of possible solutes and flow conditions. Mixing in microfluidic systems has historically been characterized by the mixing of a specific solute system or by the redistribution of flow streams; this approach does not give any insight into the ideal operational parameters of the mixer with an arbitrary real system. For Stokes-flow mixers, mixing can be computed from a relationship between solute diffusivity, flow rate, and mixer length. Confocal microscopy and computational fluid dynamics (CFD) modeling were used to directly determine the extent of mixing for several solutes in the staggered herringbone mixer over a range of Reynolds numbers (Re) and Péclet numbers (Pe); the results were used to develop and evaluate an analytical model of its behavior. Mixing was found to be a function of only Pe and downstream position in the mixer. Required mixer length was proportional to log(Pe); this analytical model matched well with the confocal data and CFD model for Pe<5 x 10(4), at which point the experiments reached the limit of resolution. For particular solutes, required length and mixing time depend upon Re and diffusivity. This analytical model is applicable to other solute systems, and possibly to other embodiments of the mixer, to enable optimal design, operation, and estimation of performance.
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Registered trials
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