ArticleJournal of Korean medical science2008
Impact of glutathione S-transferase M1 and T1 gene polymorphisms on the smoking-related coronary artery disease.
Article in Journal of Korean medical science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- An updated analysis on the association ofThe Journal of international medical research · 2022Pooled it
- An updated meta-analysis showed smoking modify the association of GSTM1 null genotype on the risk of coronary heart disease.Bioscience reports · 2021Pooled it
- Association between GSTM1 null genotype and coronary artery disease risk: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- GSTT1 null genotype contributes to coronary heart disease risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Potential Association Between Apical Periodontitis and Cardiovascular Disease: A Narrative Review of Evidence and Clinical Implications.Anatolian journal of cardiology · 2026Review
- Association of Glutathione S-TransferaseReports of biochemistry & molecular biology · 2020Article
- Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review).Molecular medicine reports · 2019Review
- Lymphocyte DNA damage and plasma antioxidant status in Korean subclinical hypertensive patients by glutathione S-transferase polymorphism.Nutrition research and practice · 2017Article
- Role of Glutathione S-Transferase in Coronary Artery Disease Patients with and Without Type 2 Diabetes Mellitus.Journal of clinical and diagnostic research : JCDR · 2017Article
- The role of oxidative DNA damage and GSTM1, GSTT1, and hOGG1 gene polymorphisms in coronary artery disease risk.Anatolian journal of cardiology · 2016Article
- Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians.Sultan Qaboos University medical journal · 2015Article
- Association of Aberrations in One Carbon Metabolism with Intimal Medial Thickening in Patients with Type 2 Diabetes Mellitus.Indian journal of clinical biochemistry : IJCB · 2015Article
- Purple grape juice supplementation in smokers and antioxidant status according to different types of GST polymorphisms.Journal of clinical biochemistry and nutrition · 2015Article
- Association of GSTT1 and GSTM1 polymorphisms with blood pressure: A Bayesian modeling of continuous data.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Glutathione S-transferase M1 (GSTM1) null genotype and coronary artery disease risk: a meta-analysis.International journal of clinical and experimental medicine · 2014Article
- Glutathione S-transferase M1 and T1 genotypes and myocardial infarction.Molecular biology reports · 2013Article
- The swollen joint, the thickened artery, and the smoking gun: tobacco exposure, citrullination and rheumatoid arthritis.Rheumatology international · 2011Review
- Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups.Genetics and molecular biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferase (GST) plays a key role in the detoxification of xenobiotic atherogen generated by smoking. To analyze the effect of GSTM1/T1 gene polymorphisms on the development of smoking-related coronary artery disease (CAD), 775 Korean patients who underwent coronary angiography were enrolled. The subjects were classified by luminal diameter stenosis into group A (>50%), B (20-50%), or C (<20%). GSTM1 and GSTT1 gene polymorphisms were analyzed using multiplex polymerase chain reaction (PCR) for GSTM1/T1 genes and CYP1A1 gene for internal control. Of 775 subjects, 403 patients belonged to group A. They had higher risk factors for CAD than group B (N=260) and group C (N=112). The genotype frequencies of null GSTM1 and GSTT1 showed no significant differences among 3 groups. Considering the effect of GSTM1 gene polymorphisms on the smoking-related CAD, smokers with GSTM1 null genotype had more increased risk for CAD than non-smoker with GSTM1 positive genotype (odds ratios [OR], 2.07, confidence interval [CI], 1.06-4.07). Also the effect of GSTT1 gene polymorphism on smoking-related CAD showed the same tendency as GSTM1 gene (OR, 2.00, CI, 1.05-3.84). This effect of GSTM1/T1 null genotype on smoking-related CAD was augmented when both gene polymorphisms were considered simultaneously (OR, 2.76, CI, 1.17-6.52). We concluded that GSTM1/T1 null genotype contributed to the pathogenesis of smoking-related CAD to some degree.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.