ArticleGenome research2008
Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Enhancer Function and Evolutionary Roles of Human Accelerated Regions.Annual review of genetics · 2022Review
- Review
- Annotating the Insect Regulatory Genome.Insects · 2021Review
- REDfly: the transcriptional regulatory element database for Drosophila.Nucleic acids research · 2019Article
- Developmental Loci Harbor Clusters of Accelerated Regions That Evolved Independently in Ape Lineages.Molecular biology and evolution · 2018Article
- Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks.Current biology : CB · 2016Article
- Accelerated evolution of constraint elements for hematophagic adaptation in mosquitoes.Dong wu xue yan jiu = Zoological research · 2015Article
- Multidimensional adaptive evolution of a feed-forward network and the illusion of compensation.Evolution; international journal of organic evolution · 2013Article
- The role of GC-biased gene conversion in shaping the fastest evolving regions of the human genome.Molecular biology and evolution · 2012Article
- Methods to detect selection on noncoding DNA.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Population genomic analysis of base composition evolution in Drosophila melanogaster.Genome biology and evolution · 2012Article
- A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis.PLoS genetics · 2012Article
- PHAST and RPHAST: phylogenetic analysis with space/time models.Briefings in bioinformatics · 2011Article
- Complex interplay of evolutionary forces in the ladybird homeobox genes of Drosophila melanogaster.PloS one · 2011Article
- Positive selection differs between protein secondary structure elements in Drosophila.Genome biology and evolution · 2010Article
- Polygenic and directional regulatory evolution across pathways in Saccharomyces.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Locus-specific decoupling of base composition evolution at synonymous sites and introns along the Drosophila melanogaster and Drosophila sechellia lineages.Genome biology and evolution · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recent genomic sequencing of 10 additional Drosophila genomes provides a rich resource for comparative genomics analyses aimed at understanding the similarities and differences between species and between Drosophila and mammals. Using a phylogenetic approach, we identified 64 genomic elements that have been highly conserved over most of the Drosophila tree, but that have experienced a recent burst of evolution along the Drosophila melanogaster lineage. Compared to similarly defined elements in humans, these regions of rapid lineage-specific evolution in Drosophila differ dramatically in location, mechanism of evolution, and functional properties of associated genes. Notably, the majority reside in protein-coding regions and primarily result from rapid adaptive synonymous site evolution. In fact, adaptive evolution appears to be driving substitutions to unpreferred codons. Our analysis also highlights interesting noncoding genomic regions, such as regulatory regions in the gene gooseberry-neuro and a putative novel miRNA.
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