ArticleStroke2008
Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study.
Article in Stroke, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03724318 (Left Atrial Appendage Closure by Surgery-2), which is not on this map. Cited by 127 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Left Atrial Appendage Closure by Surgery-2
Who cites it
127 citing papers in PubMed, 8 syntheses or guidelines pooled it, 323 citations in OpenAlex.
- Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.Circulation · 2026Pooled it
- Predictive role of atrial fibrillation in cognitive decline: a systematic review and meta-analysis of 2.8 million individuals.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Pooled it
- Incidence and Risk Factors for Silent Brain Infarction After On-Pump Cardiac Surgery: A Meta-analysis and Meta-regression of 29 Prospective Cohort Studies.Neurocritical care · 2021Pooled it
- Left Ventricular Hypertrophy and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of stroke · 2020Pooled it
- The Association between Carotid Artery Atherosclerosis and Silent Brain Infarction: A Systematic Review and Meta-analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2017Pooled it
- Guideline
- Association between atrial fibrillation and silent cerebral infarctions: a systematic review and meta-analysis.Annals of internal medicine · 2014Pooled it
- The epidemiology of silent brain infarction: a systematic review of population-based cohorts.BMC medicine · 2014Pooled it
- Adding left atrial appendage closure to open heart surgery provides protection from ischemic brain injury six years after surgery independently of atrial fibrillation history: the LAACS randomized study.Journal of cardiothoracic surgery · 2018Trial
- Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.Circulation. Arrhythmia and electrophysiology · 2016Trial
- Neurocognitive function and CNS integrity in adult survivors of childhood hodgkin lymphoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Trial
- Trial
- Link between alcohol consumption and myocardial infarction, stroke, and all-cause mortality among Swedish male automotive workers over 30 years.Scandinavian journal of primary health care · 2026Article
- Association Between Predicted 10-Year Atherosclerotic Cardiovascular Disease Risk and Magnetic Resonance Imaging-Defined Covert Brain Infarction.Journal of stroke · 2026Article
- Association of Lacunes with Risk Factors, Cognition, and Atrophy: The Multi-Ethnic Study of Atherosclerosis (MESA).medRxiv : the preprint server for health sciences · 2026Article
- Risk factors for silent cerebral infarction in immune-mediated thrombotic thrombocytopenic survivors.British journal of haematology · 2026Article
- Enlarged Perivascular Spaces Among Hispanic and Latino Adults in SOL-INCA-MRI.Journal of the American Heart Association · 2026Article
- Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia-The VasCog-2-WSO Criteria.JAMA neurology · 2025Article
- Nomogram to predict 1-year cognitive decline after stent placement for unruptured intracranial aneurysms.iScience · 2025Article
- Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
67 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposePrevious estimates of the prevalence of silent cerebral infarction (SCI) on MRI in community-based samples have varied between 5.8% and 17.7% depending on age, ethnicity, presence of comorbidities, and imaging techniques. We document the prevalence and risk factors associated with SCI at midlife in the community-based Framingham sample.
methodsOur study sample comprised 2040 Framingham Offspring (53% female; mean age, 62+/-9 years) who attended the sixth examination (1996-1998), underwent volumetric brain MRI (1999-2005,) and were free of clinical stroke at MRI. We examined the age- and sex-specific prevalences and the clinical correlates of SCI using multivariable logistic regression models.
resultsAt least 1 SCI was present in 10.7% of participants; 84% had a single lesion. SCI was largely located in the basal ganglia (52%), other subcortical (35%) areas, and cortical areas (11%). Prevalent SCI was associated with the Framingham Stroke Risk Profile score (OR, 1.27; 95% CI, 1.10-1.46); stage I hypertension was determined by JNC-7 criteria (OR,1.56; CI,1.15-2.11), an elevated plasma homocysteine in the highest quartile (OR, 2.23; CI, 1.42-3.51), atrial fibrillation (OR, 2.16; CI, 1.07-4.40), carotid stenosis >25% (OR, 1.62; 1.13-2.34), and increased carotid intimal-medial thickness above the lowest quintile (OR, 1.65; CI, 1.22-2.24).
conclusionsThe prevalence and distribution of SCI in the Framingham Offspring are comparable to previous estimates. Risk factors previously associated with clinical stroke were also found to be associated with midlife SCI. Our results support current guidelines emphasizing early detection and treatment of stroke risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.