ArticleJournal of applied physiology (Bethesda, Md. : 1985)2008
Exercise training improves peripheral chemoreflex function in heart failure rabbits.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
- Trial
- Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy.American journal of physiology. Heart and circulatory physiology · 2016Trial
- Obligatory neural feedback control of exercise cardiorespiratory function and performance.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- The new perspective of cardiac exercise rehabilitation: based on integrative physiology.Frontiers in physiology · 2025Review
- Contribution of Peripheral Chemoreceptors to Exercise Intolerance in Heart Failure.Frontiers in physiology · 2022Review
- Exercise Training Protocols in Rabbits Applied in Cardiovascular Research.Animals : an open access journal from MDPI · 2020Review
- Review
- Training heart failure patients with reduced ejection fraction attenuates muscle sympathetic nerve activation during mild dynamic exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?American journal of physiology. Heart and circulatory physiology · 2018Review
- Endurance training attenuates the increase in peripheral chemoreflex sensitivity with intermittent hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Regular physical exercise improves cardiac autonomic and muscle vasodilatory responses to isometric exercise in healthy elderly.Clinical interventions in aging · 2017Article
- Effect of exercise training on ventilatory efficiency in patients with heart disease: a review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Review
- Exercise training normalizes renal blood flow responses to acute hypoxia in experimental heart failure: role of the α1-adrenergic receptor.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Exercise training attenuates chemoreflex-mediated reductions of renal blood flow in heart failure.American journal of physiology. Heart and circulatory physiology · 2015Article
- Modulation of angiotensin II signaling following exercise training in heart failure.American journal of physiology. Heart and circulatory physiology · 2015Review
- Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure.American journal of physiology. Heart and circulatory physiology · 2015Review
- Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure.Autonomic neuroscience : basic & clinical · 2015Review
- Mechanisms of carotid body chemoreflex dysfunction during heart failure.Experimental physiology · 2015Review
- Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure.BioMed research international · 2015Review
- Simvastatin treatment attenuates increased respiratory variability and apnea/hypopnea index in rats with chronic heart failure.Hypertension (Dallas, Tex. : 1979) · 2014Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
An enhancement of peripheral chemoreflex sensitivity contributes to sympathetic hyperactivity in chronic heart failure (CHF) rabbits. The enhanced chemoreflex function in CHF involves augmented carotid body (CB) chemoreceptor activity via upregulation of the angiotensin II (ANG II) type 1 (AT(1))-receptor pathway and downregulation of the neuronal nitric oxide synthase (nNOS)-nitric oxide (NO) pathway in the CB. Here we investigated whether exercise training (EXT) normalizes the enhanced peripheral chemoreflex function in CHF rabbits and possible mechanisms mediating this effect. EXT partially, but not fully, normalized the exaggerated baseline renal sympathetic nerve activity (RSNA) and the response of RSNA to hypoxia in CHF rabbits. EXT also decreased the baseline CB nerve single-fiber discharge (4.9 +/- 0.4 vs. 7.7 +/- 0.4 imp/s at Po(2) = 103 +/- 2.3 Torr) and the response to hypoxia (20.6 +/- 1.1 vs. 36.3 +/- 1.3 imp/s at Po(2) = 41 +/- 2.2 Torr) from CB chemoreceptors in CHF rabbits, which could be reversed by treatment of the CB with ANG II or a nNOS inhibitor. Our results also showed that NO concentration and protein expression of nNOS were increased in the CBs from EXT + CHF rabbits, compared with that in CHF rabbits. On the other hand, elevated ANG II concentration and AT(1)-receptor overexpression of the CBs in CHF state were blunted by EXT. These results indicate that EXT normalizes the CB chemoreflex in CHF by preventing an increase in afferent CB chemoreceptor activity. EXT reverses the alterations in the nNOS-NO and ANG II-AT(1)-receptor pathways in the CB responsible for chemoreceptor sensitization in CHF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.