ArticleNucleic acids research2008
Filament formation and robust strand exchange activities of the rice DMC1A and DMC1B proteins.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Investigation of mechanisms underlying seedlessness in a Sangiovese somatic variant through comparative genomic and histological analyses.BMC plant biology · 2025Article
- Genetic and molecular mechanisms underlying the male sterility in rice.Journal of applied genetics · 2025Review
- Generation of Asynaptic Mutants in Potato by DisruptingLife (Basel, Switzerland) · 2023Article
- The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination.iScience · 2022Article
- Novel Homozygous Pathogenic Mutations of LAMA 2 Gene in Patients with Congen ital Muscular Dystrophy.Iranian journal of child neurology · 2021Article
- In Planta Processing of the SpCas9-gRNA Complex.Plant & cell physiology · 2017Article
- The Rice AAA-ATPase OsFIGNL1 Is Essential for Male Meiosis.Frontiers in plant science · 2017Article
- Precision Targeted Mutagenesis via Cas9 Paired Nickases in Rice.Plant & cell physiology · 2016Article
- Entamoeba histolytica Dmc1 Catalyzes Homologous DNA Pairing and Strand Exchange That Is Stimulated by Calcium and Hop2-Mnd1.PloS one · 2015Article
- Sufficient amounts of functional HOP2/MND1 complex promote interhomolog DNA repair but are dispensable for intersister DNA repair during meiosis in Arabidopsis.The Plant cell · 2013Article
- Article
- Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing.Nucleic acids research · 2012Article
- Plant DNA recombinases: a long way to go.Journal of nucleic acids · 2010Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The DMC1 protein, a meiosis-specific DNA recombinase, catalyzes strand exchange between homologous chromosomes. In rice, two Dmc1 genes, Dmc1A and Dmc1B, have been reported. Although the Oryza sativa DMC1A protein has been partially characterized, however the biochemical properties of the DMC1B protein have not been defined. In the present study, we expressed the Oryza sativa DMC1A and DMC1B proteins in bacteria and purified them. The purified DMC1A and DMC1B proteins formed helical filaments along single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA), and promoted robust strand exchange between ssDNA and dsDNA over five thousand base pairs in the presence of RPA, as a co-factor. The DMC1A and DMC1B proteins also promoted strand exchange in the absence of RPA with long DNA substrates containing several thousand base pairs. In contrast, the human DMC1 protein strictly required RPA to promote strand exchange with these long DNA substrates. The strand-exchange activity of the Oryza sativa DMC1A protein was much higher than that of the DMC1B protein. Consistently, the DNA-binding activity of the DMC1A protein was higher than that of the DMC1B protein. These biochemical differences between the DMC1A and DMC1B proteins may provide important insight into their functional differences during meiosis in rice.
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