ArticleThe American journal of pathology2008
Growth hormone promotes lymphangiogenesis.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- GH Alters Lymphatic Vessels in Female Mice and STAT5 Phosphorylation in Human Lymphatic Endothelial Cells.Endocrinology · 2026Article
- Growth Hormone Receptor Antagonist Markedly Improves Gemcitabine Response in a Mouse Xenograft Model of Human Pancreatic Cancer.International journal of molecular sciences · 2024Article
- Alternative splicing of leptin receptor overlapping transcript in osteosarcoma.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Broad targeting of angiogenesis for cancer prevention and therapy.Seminars in cancer biology · 2015Review
- Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma.Experimental & molecular medicine · 2014Article
- Is there a risk of pubertal worsening in primary intestinal lymphangiectasia?Journal of endocrinological investigation · 2013Article
- Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration.Angiogenesis · 2013Article
- Macrophage-mediated lymphangiogenesis: the emerging role of macrophages as lymphatic endothelial progenitors.Cancers · 2012Article
- Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells.The American journal of pathology · 2012Article
- Tumor lymphangiogenesis as a potential therapeutic target.Journal of oncology · 2012Article
- Article
- A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development.Journal of vascular research · 2011Article
- Article
- Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis and lymphatic function.Matrix biology : journal of the International Society for Matrix Biology · 2010Review
- Microanatomy of the intestinal lymphatic system.Annals of the New York Academy of Sciences · 2010Article
- Lymphangiogenesis and lymphatic metastasis in breast cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2010Article
- Article
- Lymphangiogenesis and cancer metastasis.Journal of cellular and molecular medicine · 2009Review
- Developmental and pathological lymphangiogenesis: from models to human disease.Histochemistry and cell biology · 2008Review
- The lymphatic system in health and disease.Lymphatic research and biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The lymphatic system plays an important role in inflammation and cancer progression, although the molecular mechanisms involved are poorly understood. As determined using comparative transcriptional profiling studies of cultured lymphatic endothelial cells versus blood vascular endothelial cells, growth hormone receptor was expressed at much higher levels in lymphatic endothelial cells than in blood vascular endothelial cells. These findings were confirmed by quantitative real-time reverse transcriptase-polymerase chain reaction and Western blot analyses. Growth hormone induced in vitro proliferation, sprouting, tube formation, and migration of lymphatic endothelial cells, and the mitogenic effect was independent of vascular endothelial growth factor receptor-2 or -3 activation. Growth hormone also inhibited serum starvation-induced lymphatic endothelial cell apoptosis. No major alterations of lymphatic vessels were detected in the normal skin of bovine growth hormone-transgenic mice. However, transgenic delivery of growth hormone accelerated lymphatic vessel ingrowth into the granulation tissue of full-thickness skin wounds, and intradermal delivery of growth hormone resulted in enlargement and enhanced proliferation of cutaneous lymphatic vessels in wild-type mice. These results identify growth hormone as a novel lymphangiogenic factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.