ArticleMutation research2008
Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis.
Article in Mutation research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Histopathologic effects of mobile phone radiation exposure on the testes and sperm parameters: a systematic literature review of animal studies.Frontiers in reproductive health · 2024Pooled it
- Annulus fracture underlies radiation-induced sperm dysfunction revealed by multimodal nano-imaging.Life science alliance · 2026Article
- Male infertility as a late side effect of oncological treatment of Hodgkin lymphoma in childhood and adolescents and the possible prevention.Frontiers in oncology · 2025Review
- Low-Dose Ionizing Radiation Exposure on Human Male Gametes: Damage or Benefit.Life (Basel, Switzerland) · 2024Review
- Ultrastructural Analysis of Large Japanese Field Mouse (Biology · 2024Article
- Metformin Ameliorates 2.856 GHz Microwave- Radiation-Induced Reproductive Impairments in Male Rats via Inhibition of Oxidative Stress and Apoptosis.International journal of molecular sciences · 2023Article
- Modulatory effects of Punica granatum L juice against 2115 MHz (3G) radiation-induced reproductive toxicity in male Wistar rat.Environmental science and pollution research international · 2021Article
- Radiations and male fertility.Reproductive biology and endocrinology : RB&E · 2018Review
- Maternal exposure to radiographic exams and major structural birth defects.Birth defects research. Part A, Clinical and molecular teratology · 2016Article
- Maternal occupational exposure to ionizing radiation and major structural birth defects.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- Early-life exposure to benzo[a]pyrene increases mutant frequency in spermatogenic cells in adulthood.PloS one · 2014Article
- Characterization and expression pattern of p53 during spermatogenesis in the Chinese mitten crab Eriocheir sinensis.Molecular biology reports · 2013Article
- Enhanced genetic integrity in mouse germ cells.Biology of reproduction · 2013Article
- Ionizing radiation-induced mutant frequencies increase transiently in male germ cells of older mice.Mutation research · 2012Article
- Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture.Biomaterials · 2011Article
- BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice.Biology of reproduction · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Humans are exposed to ionizing radiation (IR) under various circumstances, e.g. cosmic radiation, diagnostic X-rays and radiotherapy for cancer. It has been shown that IR can impair spermatogenesis and can cause mutations in germ cells. However, the mutagenic responses of germ cells exposed to IR at different stages of testicular maturation have not been examined by directly assessing the mutant frequency in defined spermatogenic cell types. This study was performed to address whether preadult exposure to IR can increase mutations in adult germ cells that could in turn have a major impact on adult reproductive function and the health of ensuing offspring. Male Lac I transgenic mice were irradiated with a single dose of 2.5 Gy of gamma-ray at different ages before adulthood, reflecting different stages of testicular maturation, and then mutant frequency (MF) was determined directly in spermatogenic cell types emanating from the irradiated precursor cells. The results showed that (1) preadult exposure to IR did not significantly increase MF in adult epididymal spermatozoa; (2) spermatogenic stages immediately following the irradiated stage(s) displayed an elevated mutant frequency; but (3) the mutant frequency was restored to unirradiated levels in later stages of spermatogenesis. These findings provide evidence that there is a mechanism(s) to prevent spermatogenic cells with elevated mutant frequencies from progressing through spermatogenesis.
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Registered trials
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