ArticleMalaria journal2008
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection.
Article in Malaria journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- Malaria in Cambodia: A Retrospective Analysis of a Changing Epidemiology 2006-2019.International journal of environmental research and public health · 2021Article
- Article
- Evaluation of Plasmodium falciparum MSP10 and its development as a serological tool for the Peruvian Amazon region.Malaria journal · 2019Article
- Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.The Journal of infectious diseases · 2019Article
- Antibodies elicited during natural infection in a predominantly Plasmodium falciparum transmission area cross-react with sexual stage-specific antigen in P. vivax.Acta tropica · 2017Article
- Article
- Malaria and immunity during pregnancy and postpartum: a tale of two species.Parasitology · 2015Review
- Sensitivity and specificity of PS/AA-modified nanoparticles used in malaria detection.Microbial biotechnology · 2013Article
- Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals.Infection and immunity · 2010Article
- Immune response to Plasmodium vivax has a potential to reduce malaria severity.Clinical and experimental immunology · 2010Article
- Why do adaptive immune responses cross-react?Evolutionary applications · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has frequently been reported that Plasmodium vivax suppressed Plasmodium falciparum and ameliorated disease severity in patients infected with these two species simultaneously. The authors investigate the hypothesis that immunological responses stimulated by P. vivax may play a role in suppressing co-infecting P. falciparum.
methodsSera, taken sequentially from one of the authors (YN) during experimental infection with P. vivax, were added to in vitro cultures of P. falciparum. Cross-reactive antibodies against P. falciparum antigens, and cytokines were measured in the sera.
resultsSignificant growth inhibitory effects upon P. falciparum cultures (maximally 68% inhibition as compared to pre-illness average) were observed in the sera collected during an acute episode. Such inhibitory effects showed a strong positive temporal correlation with cross-reactive antibodies, especially IgM against P. falciparum schizont extract and, to a lesser degree, IgM against Merozoite Surface Protein (MSP)-119. Interleukin (IL)-12 showed the highest temporal correlation with P. vivax parasitaemia and with body temperatures in the volunteer.
conclusionThese results suggest the involvement by cross-reactive antibodies, especially IgM, in the interplay between plasmodial species. IL-12 may be one of direct mediators of fever induction by rupturing P. vivax schizonts, at least in some subjects. Future studies, preferably of epidemiological design, to reveal the association between cross-reactive IgM and cross-plasmodial interaction, are warranted.
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