ArticleWorld journal of surgical oncology2008
Intraoperative frozen section assessment of sentinel lymph nodes in the operative management of women with symptomatic breast cancer.
Article in World journal of surgical oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Sentinel node biopsy alone for breast cancer patients with residual nodal disease after neoadjuvant chemotherapy.Scientific reports · 2021Trial
- Article
- False-negative frozen section of sentinel nodes in early breast cancer (cT1-2N0) patients.World journal of surgical oncology · 2021Article
- Article
- Sentinel lymph nodes for breast carcinoma: an update on current practice.Histopathology · 2016Review
- Evaluation of the benefit of routine intraoperative frozen section analysis of sentinel lymph nodes in breast cancer.ISRN oncology · 2013Article
- NOTES: The question for minimal resection and sentinel node in early gastric cancer.World journal of gastrointestinal surgery · 2010Article
- Could lymphatic mapping and sentinel node biopsy provide oncological providence for local resectional techniques for colon cancer? A review of the literature.BMC surgery · 2008Review
- Can Complete Axillary Node Dissection Be Safely Omitted in Patients with Early Breast Cancer When the Sentinel Node Biopsy Is Positive for Malignancy? An Update for Clinical Practice.In vivo (Athens, Greece)Review
- Optical coherence tomography: the intraoperative assessment of lymph nodes in breast cancer.IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology SocietyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaximisation of the potential of sentinel lymph node biopsy as a minimally invasive method of axillary staging requires sensitive intraoperative pathological analysis so that rates of re-operation for lymphatic metastases are minimised. The aim of this study was to describe the test parameters of the frozen section evaluation of sentinel node biopsy for breast cancer compared to the gold standard of standard permanent pathological evaluation at our institution.
methodsThe accuracy of intraoperative frozen section (FS) of sentinel nodes was determined in 94 consecutive women undergoing surgery for clinically node negative, invasive breast cancer (37:T1 disease; 43:T2; 14:T3). Definitive evidence of lymphatic spread on FS indicated immediate level II axillary clearance while sentinel node "negativity" on intraoperative testing led to the operation being curtailed to allow formal H&E analysis of the remaining sentinel nodal tissue.
resultsIntraoperative FS correctly predicted axillary involvement in 23/30 patients with lymphatic metastases (76% sensitivity rate) permitting definitive surgery to be completed at the index operation in 87 women (93%) overall. All SN found involved on FS were confirmed as harbouring tumour cells on subsequent formal specimen examination (100% specificity and positive predictive value) with 16 patients having additional non-sentinel nodes found also to contain tumour. Negative Predictive Values were highest in women with T1 tumours (97%) and lessened with more local advancement of disease (T2 rates: 86%; T3: 75%). Of those with falsely negative FS, three had only micrometastatic disease.
conclusionIntraoperative FS reliably evaluates the status of the sentinel node allowing most women complete their surgery in a single stage. Thus SN can be offered with increased confidence to those less likely to have negative axillae hence expanding the population of potential beneficiaries.
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