ArticleInfection control and hospital epidemiology2008
Is an increased dwell time of a peripherally inserted catheter associated with an increased risk of bloodstream infection in infants?
Article in Infection control and hospital epidemiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.Intensive care medicine · 2020Guideline
- Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Complications and Related Risk Factors of Peripherally Inserted Central Catheters in Neonates: A Historical Cohort Study.Archives of Iranian medicine · 2023Article
- Central Venous Catheter-Related Infectious Complications in Pediatric Surgical Patients: A Single-Center Experience.Journal of pediatric intensive care · 2022Article
- Effect of Catheter Dwell Time on Risk of Central Line-Associated Bloodstream Infection in Infants.Pediatrics · 2015Article
- Catheter dwell time and CLABSIs in neonates with PICCs: a multicenter cohort study.Pediatrics · 2013Article
- Risk factors and prevention of late-onset sepsis in premature infants.Early human development · 2010Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo estimate the risk of bloodstream infection associated with catheter dwell time in infants.
designRetrospective study.
settingDuke University Medical Center neonatal intensive care unit, an academic, level 3 nursery in Durham, North Carolina.
methodsA case of catheter-associated bloodstream infection was defined as one that occurred in an infant whose culture-positive blood sample was collected more than 24 hours after catheter insertion or within 72 hours after catheter removal. We used multivariable logistic regression to control for the catheter's position and dwell time as well as the infant's sex, gestational age, age at time of catheter insertion, birth weight, and weight at time of catheter insertion.
resultsWe identified 135 cases of catheter-associated bloodstream infection. The mean catheter dwell time was 12.2 days (range, 0-113 days), and the mean time to bloodstream infection was 10.8 days (range, 1-57 days). An increase in catheter dwell time was associated with a lower risk of bloodstream infection (odds ratio, 0.975 [95% confidence interval, 0.954-0.996]; P = .02).
conclusionNo increased risk of catheter-associated bloodstream infection was observed with increased catheter dwell time. This may have been due to the infant's improved nutrition, decreased need for other invasive devices, and maturing skin and immune system as catheter dwell time increased.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.