ArticleJournal of molecular neuroscience : MN2009
Electroacupuncture induced spinal plasticity is linked to multiple gene expressions in dorsal root deafferented rats.
Article in Journal of molecular neuroscience : MN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study.Acta veterinaria Scandinavica · 2010Trial
- EA Improves the Motor Function in Rats with Spinal Cord Injury by Inhibiting Signal Transduction of Semaphorin3A and Upregulating of the Peripheral Nerve Networks.Neural plasticity · 2020Article
- Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects.Neural plasticity · 2020Review
- Electro-acupuncture-induced neuroprotection is associated with activation of the IGF-1/PI3K/Akt pathway following adjacent dorsal root ganglionectomies in rats.International journal of molecular medicine · 2019Article
- Endogenous neurotrophin-3 promotes neuronal sprouting from dorsal root ganglia.Neural regeneration research · 2015Article
- Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats.Neurochemical research · 2015Article
- The holistic effects of acupuncture treatment.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Electro-acupuncture treatment improves neurological function associated with downregulation of PDGF and inhibition of astrogliosis in rats with spinal cord transection.Journal of molecular neuroscience : MN · 2013Article
- Electroacupuncture improves thermal and mechanical sensitivities in a rat model of postherpetic neuralgia.Molecular pain · 2013Article
- Understanding Acupuncture Based on ZHENG Classification from System Perspective.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Gene Expression Profiles at Moxibustioned Site (ST36): A Microarray Analysis.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Systems biology of meridians, acupoints, and chinese herbs in disease.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Effects of electro-acupuncture on IGF-I expression in spared dorsal root ganglia and associated spinal dorsal horn in cats subjected to adjacent dorsal root ganglionectomies.Neurochemical research · 2009Article
- Use of serial analysis of gene expression to reveal the specific regulation of gene expression profile in asthmatic rats treated by acupuncture.Journal of biomedical science · 2009Article
- Electroacupuncture anesthesia for laparotomy in goats.Open veterinary journalArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The underlying mechanism for electroacupuncture (EA) associated functional improvement in patients suffering from spinal cord injury (SCI) is largely unknown. Collateral sprouting is one plausible factor, where the cord microenvironment may contribute greatly. The present study evaluated the effects of EA on collateral sprouting from spared dorsal root ganglion (DRG), sensory functional restorations, and differential gene expressions in spinal cord after partial DRG removal in the rat. Following EA, N1 waveform latencies for cortical somatosensory evoked potential significantly shortened. The densities of terminal sprouting from the spared DRG significantly increased on the EA versus the non-EA side. Microarray analysis revealed that several genes were upregulated on the acupunctured side at different time points; they were ciliary neurotrophic factor (CNTF) at 1 day postoperation (dpo), fibroblast growth factor (FGF)-1, insulin-like growth factor (IGF) 1 receptor, neuropeptide Y, and FGF-13 at 7 dpo, and CNTF and calcitonin gene-related polypeptide-alpha at 14 dpo, respectively. Meanwhile, five genes (CNTF, p75-like apoptosis-inducing death domain protein, IGF-1, transforming growth factor-beta 2, and FGF-4) were downregulated at 7 dpo. Furthermore, reverse transcriptase polymerase chain reaction results supported the gene chip analysis. It was concluded that the EA induced sensory functional restorations following partial DRG ganglionectomies could be brought about by intraspinal sprouting from the spared DRG, as well as multiple differential gene expressions in the spinal cord. The results could have clinical application in EA treatment of patients after spinal injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.