ArticleWorld journal of urology2008
Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats.
Article in World journal of urology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of an alpha-1d adrenoreceptor antagonist (naftopidil) on bladder dysfunction after radiotherapy in female rats.International urogynecology journal · 2021Article
- Expression of bladder αInvestigative and clinical urology · 2020Article
- Research Findings on Overactive Bladder.Current urology · 2015Review
- Neural control of the lower urinary tract.Comprehensive Physiology · 2015Review
- The aging effects on phenylephrine-induced relaxation of bladder in mice.Tzu chi medical journalArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesA possibility that aging affects (a) expression of the alpha1D-adrenergic receptor (AR1D), (b) AR1D-mediated contractions and (c) sympathetic innervation in the urinary bladder in rats was studied. MATERIALS AND
methodsContraction produced by phenylephrine and inhibition of these contractions by a non-selective alpha1-adrenergic antagonist prazosin and a selective AR1D antagonist BMY7378 were compared between 6- and 24-month-old Fisher rats. Expressions of VMAT and AR1D in the bladder were assessed by immunofluorescence and Western blot.
resultsPhenylephrine-induced contractions were larger and inhibition of these contractions by BMY7378 was significantly greater in 24-month-old rats. Aging increased expression of AR1D in the bladder. Density of VMAT-immunoreactive neurites was decreased in smooth muscle but elevated in the suburothelial region of 24-month-old rats.
conclusionsThe results suggest that influence of adrenergic activity on bladder contractility increases with aging is due to overexpression of the AR1D. Influence of adrenergic activity on the urothelial function may also be enhanced with aging.
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