Evidence map›Paper›PMID 18580296›Full record

ArticleExercise and sport sciences reviews2008

Sex hormone effects on body fluid regulation.

Nina S Stachenfeld

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Exercise and sport sciences reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07591818 (Menstrual Cycle and Oral Contraceptive Use in Athletic Performance and Health-related Hydration and Energy Balance Status), which is not on this map. Cited by 90 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 5 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07591818 recruitingnot on this mapstarted 2026, after this paper: background citation

Menstrual Cycle and Oral Contraceptive Use in Athletic Performance and Health-related Hydration and Energy Balance Status

TypeobservationalSponsorFaculdade de Motricidade HumanaRan2026 to 2028Enrolled40ConditionsMenstrual Cycle, Oral Contraceptive Use, Athlete
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 5 syntheses or guidelines pooled it, 202 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Pooled it
  6. Copeptin kinetics in healthy aging.The Journal of clinical endocrinology and metabolism · 2026
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  13. Effects of a ketogenic diet on body composition and strength in trained women.Journal of the International Society of Sports Nutrition · 2020
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  14. Rehydrating efficacy of maple water after exercise-induced dehydration.Journal of the International Society of Sports Nutrition · 2019
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  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Nina S StachenfeldThe John B. Pierce Laboratory and Yale University School of Medicine, New Haven, CT 06519, United States. nstach@jbpierce.org
John B. Pierce Laboratory · US

Funding

Estrogen &Progesterone Effects on Orthostatic ToleranceR01HL071159 · NHLBI · JOHN B. PIERCE LABORATORY, INC. · PI STACHENFELD, NINA · 2003 to 2010
$3.2M
SEX HORMONES AND BODY FLUID REGULATIONR01HL062240 · NHLBI · JOHN B. PIERCE LABORATORY, INC. · PI STACHENFELD, NINA · 2000 to 2003
$1.1M
NHLBI NIH HHS R01 HL062240NHLBI NIH HHS R01 HL071159NHLBI NIH HHS R01 HL62240NHLBI NIH HHS R01 HL71159
6 · The paper itself

Abstract

In young women, estradiol and progesterone primarily control reproduction, but they also affect fluid regulation. Estradiol lowers the operating point for osmoregulation of arginine vasopressin and thirst and increases plasma volume. Although total body water and sodium content are only mildly affected, data presented in this article suggest that reproductive hormones alter homeostatic set points for body fluid and tonicity.

Indexed as

Arginine VasopressinBody FluidsEstradiolFemaleGonadotropin-Releasing HormoneHomeostasisHumansLeuprolideMaleProgesteroneSaline Solution, HypertonicSodiumThirstWater-Electrolyte BalanceArginine VasopressinEstradiolganirelixGonadotropin-Releasing HormoneLeuprolideProgesteroneSaline Solution, HypertonicSodium

Identifiers

PMID18580296
PMCPMC2849969
OpenAlexW2104432151

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.