ArticleExercise and sport sciences reviews2008
Altered mechanisms of thermoregulatory vasoconstriction in aged human skin.
Article in Exercise and sport sciences reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- National Athletic Trainers' Association position statement: environmental cold injuries.Journal of athletic trainingGuideline
- Cold-induced vasodilation: A meta-analysis.Temperature (Austin, Tex.) · 2026Review
- Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Review
- Analysis on fluid intake and urination behaviors among the elderly in five cities in China: a cross-sectional study.Frontiers in nutrition · 2023Article
- Nitric oxide-mediated inhibition of phenylephrine-induced contraction in response to hypothermia is partially modulated by endothelial Rho-kinase.International journal of medical sciences · 2020Article
- Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow.European journal of applied physiology · 2020Review
- Level of Cutaneous Blood Flow Depression During Cryotherapy Depends on Applied Temperature: Criteria for Protocol Design.Journal of engineering and science in medical diagnostics and therapy · 2018Article
- Cold adaptation, aging, and Korean women divers haenyeo.Journal of physiological anthropology · 2017Review
- Neurovascular mechanisms underlying augmented cold-induced reflex cutaneous vasoconstriction in human hypertension.The Journal of physiology · 2017Article
- Two nights of sleep deprivation with or without energy restriction does not impair the thermal response to cold.European journal of applied physiology · 2015Article
- Exercise training and the control of skin blood flow in older adults.The journal of nutrition, health & aging · 2012Review
- Cutaneous sympathetic neural responses to body cooling in type 2 diabetes mellitus.Autonomic neuroscience : basic & clinical · 2011Article
- Local thermal control of the human cutaneous circulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Water, hydration, and health.Nutrition reviews · 2010Review
- Effect of aging on cardiac function during cold stress in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Aging and the control of human skin blood flow.Frontiers in bioscience (Landmark edition) · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Human exposure to cold stimulates cutaneous vasoconstriction by activating both sympathetic reflex and locally mediated pathways. Older humans are vulnerable to hypothermia because primary aging impairs thermoregulatory cutaneous vasoconstriction. This article highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairment, whereas changes in local cold-induced intracellular signaling suggest a more generalized age-associated vascular dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.