ArticleRNA (New York, N.Y.)2008
Computational analysis of miRNA-mediated repression of translation: implications for models of translation initiation inhibition.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
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- Systemic CLIP-seq analysis and game theory approach to model microRNA mode of binding.Nucleic acids research · 2021Article
- Underexpression ofInternational journal of reproductive biomedicine · 2021Article
- Sex Differences in the Expression of the α5 Subunit of the GABAAlcoholism, clinical and experimental research · 2020Article
- Understanding microRNA-mediated gene regulatory networks through mathematical modelling.Nucleic acids research · 2016Article
- Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans.Nucleic acids research · 2016Article
- Integrated genomic analysis identifies subclasses and prognosis signatures of kidney cancer.Oncotarget · 2015Article
- Cooperative gene regulation by microRNA pairs and their identification using a computational workflow.Nucleic acids research · 2014Article
- Article
- Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs.Nucleic acids research · 2012Article
- Kinetic signatures of microRNA modes of action.RNA (New York, N.Y.) · 2012Article
- MicroRNAs and ovarian function.Journal of ovarian research · 2012Article
- PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro.The EMBO journal · 2011Article
- A model-based strategy to investigate the role of microRNA regulation in cancer signalling networks.Theory in biosciences = Theorie in den Biowissenschaften · 2011Article
- Slowly produced microRNAs control protein levels.The Journal of biological chemistry · 2011Article
- A parsimonious model for gene regulation by miRNAs.Science (New York, N.Y.) · 2011Review
- The microRNA pathway and cancer.Cancer science · 2010Review
- Molecular cloning and expression profiles of Argonaute proteins in Schistosoma japonicum.Parasitology research · 2010Article
- How do miRNAs mediate translational repression?Silence · 2010Article
- Dynamical modeling of microRNA action on the protein translation process.BMC systems biology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism by which miRNAs inhibit translation has been under scrutiny both in vivo and in vitro. Divergent results have led to the suggestion that miRNAs repress translation by a variety of mechanisms including blocking the function of the cap in stimulating translation. However, these analyses largely only examine the final output of the multistep process of translation. This raises the possibility that when different steps in translation are rate limiting, miRNAs might show different effects on protein production. To examine this possibility, we modeled the process of translation initiation and examined how the effects of miRNAs under different conditions might be explained. Our results suggest that different effects of miRNAs on protein production in separate experiments could be due to differences in rate-limiting steps. This analysis does not rule out that miRNAs directly repress the function of the cap structure, but it demonstrates that the observations used to argue for this effect are open to alternative interpretations. Taking all the data together, our analysis is consistent with the model that miRNAs may primarily repress translation initiation at a late step.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.