ArticleJournal of the American Medical Informatics Association : JAMIA
Methodologic issues in health informatics trials: the complexities of complex interventions.
Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of eHealth on the quality and safety of health care: a systematic overview.PLoS medicine · 2011Pooled it
- Standards for reporting randomized controlled trials in medical informatics: a systematic review of CONSORT adherence in RCTs on clinical decision support.Journal of the American Medical Informatics Association : JAMIAPooled it
- Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial.Nature medicine · 2025Trial
- Evaluating the Effect of a COVID-19 Predictive Model to Facilitate Discharge: A Randomized Controlled Trial.Applied clinical informatics · 2022Trial
- Individualized electronic decision support and reminders to improve diabetes care in the community: COMPETE II randomized trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2009Trial
- Personal health records and hypertension control: a randomized trial.Journal of the American Medical Informatics Association : JAMIATrial
- Multisite Pragmatic Cluster-Randomized Controlled Trial of the CONCERN Early Warning System.medRxiv : the preprint server for health sciences · 2024Article
- Evaluation of a Clinical Decision Support Strategy to Increase Seasonal Influenza Vaccination Among Hospitalized Children Before Inpatient Discharge.JAMA network open · 2021Article
- Asynchronous mHealth Interventions in Rheumatoid Arthritis: Systematic Scoping Review.JMIR mHealth and uHealth · 2020Article
- Effects of an electronic reminder system on guideline-concordant treatment of psychotic disorders : Results from a pilot feasibility trial.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2016Article
- Macroergonomics in Healthcare Quality and Patient Safety.Review of human factors and ergonomics · 2013Article
- Adopting electronic medical records: are they just electronic paper records?Canadian family physician Medecin de famille canadien · 2013Article
- Translating clinical informatics interventions into routine clinical care: how can the RE-AIM framework help?Journal of the American Medical Informatics Association : JAMIAArticle
- The role of information technology in translating educational interventions into practice: an analysis using the PRECEDE/PROCEED model.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE All electronic health (e-health) interventions require validation as health information technologies, ideally in randomized controlled trial settings. However, as with other types of complex interventions involving various active components and multiple targets, health informatics trials often experience problems of design, methodology, or analysis that can influence the results and acceptance of the research. Our objective was to review selected key methodologic issues in conducting and reporting randomized controlled trials in health informatics, provide examples from a recent study, and present practical recommendations. DESIGN For illustration, we use the COMPETE III study, a large randomized controlled clinical trial investigating the impact of a shared decision-support system on the quality of vascular disease management in Ontario, Canada. RESULTS We describe a set of methodologic, logistic, and statistical issues that should be considered when planning and implementing trials of complex e-health interventions, and provide practical recommendations for health informatics trialists. CONCLUSIONS Our recommendations emphasize validity and pragmatic considerations and would be useful for health informaticians conducting or evaluating e-health studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.