ArticleAmerican journal of physiology. Cell physiology2008
Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts.
Article in American journal of physiology. Cell physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by AmilorideFrontiers in physiology · 2021Article
- Dynamic Palmitoylation of the Sodium-Calcium Exchanger Modulates Its Structure, Affinity for Lipid-Ordered Domains, and Inhibition by XIP.Cell reports · 2020Article
- Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin.The Journal of general physiology · 2020Article
- Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons.Nature communications · 2015Article
- Channel properties of Nax expressed in neurons.PloS one · 2015Article
- Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium.Arthritis research & therapy · 2014Article
- NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels.The Journal of biological chemistry · 2014Article
- ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95.PloS one · 2014Article
- Acid-sensing ion channels: trafficking and synaptic function.Molecular brain · 2013Review
- Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition.American journal of physiology. Cell physiology · 2013Article
- The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry.The Journal of biological chemistry · 2012Article
- Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95.Biochemical and biophysical research communications · 2012Article
- Article
- Acute cholesterol-induced anti-natriuretic effects: role of epithelial Na+ channel activity, protein levels, and processing.The Journal of biological chemistry · 2011Article
- Activity and PI3-kinase dependent trafficking of the intestinal anion exchanger downregulated in adenoma depend on its PDZ interaction and on lipid rafts.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release.Annals of the rheumatic diseases · 2010Article
- ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons.Circulation research · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Acid-sensing ion channel 3 (ASIC3) is a H(+)-gated cation channel primarily found in sensory neurons, where it may function as a pH sensor in response to metabolic disturbances or painful conditions. We previously found that ASIC3 interacts with the postsynaptic density protein PSD-95 through its COOH terminus, which leads to a decrease in ASIC3 cell surface expression and H(+)-gated current. PSD-95 has been implicated in recruiting proteins to lipid rafts, which are membrane microdomains rich in cholesterol and sphingolipids that organize receptor/signaling complexes. We found ASIC3 and PSD-95 coimmunoprecipitated within detergent-resistant membrane fractions. When cells were exposed to methyl-beta-cyclodextrin to deplete membrane cholesterol and disrupt lipid rafts, PSD-95 localization to lipid raft fractions was abolished and no longer inhibited ASIC3 current. Likewise, mutation of two cysteine residues in PSD-95 that undergo palmitoylation (a lipid modification that targets PSD-95 to lipid rafts) prevented its inhibition of ASIC3 current and cell surface expression. In addition, we found that cell surface ASIC3 is enriched in the lipid raft fraction. These data suggest that PSD-95 and ASIC3 interact within lipid rafts and that this raft interaction is required for PSD-95 to modulate ASIC3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.