Evidence map›Paper›PMID 18579753›Full record

ReviewPharmacological reviews2008

Vascular actions of estrogens: functional implications.

Virginia M Miller, Sue P Duckles

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacological reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 277 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed, 6 pooled it
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 6 syntheses or guidelines pooled it, 560 citations in OpenAlex.

  1. Pooled it
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  6. Long-term hormone therapy for perimenopausal and postmenopausal women.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Trial
  8. Trial
  9. Differential effects of hormone therapy on serotonin, vascular function and mood in the KEEPS.Climacteric : the journal of the International Menopause Society · 2016
    Trial
  10. Role of the ovarian cycle on neural cardiovascular control in sleep-deprived women.Journal of applied physiology (Bethesda, Md. : 1985) · 2015
    Trial
  11. Review
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  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Virginia M MillerSurgery and Physiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. miller.virginia@mayo.edu
Sue P Duckles
Mayo Clinic in Florida · USUniversity of California, Irvine · US

Funding

VASCULAR REACTIVITY--GENDER AND HORMONAL INFLUENCESR01HL050775 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DUCKLES, SUE P · 1994 to 2011
$4.3M
Thrombosis Propensity Determinants of InflammationR01HL078638 · NHLBI · MAYO CLINIC ROCHESTER · PI OWEN, WHYTE G · 2004 to 2007
$1.2M
ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIESR01HL051736 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI MILLER, VIRGINIA M · 1994 to 2002
$1.0M
NHLBI NIH HHS HL-50775NHLBI NIH HHS HL-51736NHLBI NIH HHS HL-78638NHLBI NIH HHS R01 HL050775NHLBI NIH HHS R01 HL078638
6 · The paper itself

Abstract

The impact of estrogen exposure in preventing or treating cardiovascular disease is controversial. But it is clear that estrogen has important effects on vascular physiology and pathophysiology, with potential therapeutic implications. Therefore, the goal of this review is to summarize, using an integrated approach, current knowledge of the vascular effects of estrogen, both in humans and in experimental animals. Aspects of estrogen synthesis and receptors, as well as general mechanisms of estrogenic action are reviewed with an emphasis on issues particularly relevant to the vascular system. Recent understanding of the impact of estrogen on mitochondrial function suggests that the longer lifespan of women compared with men may depend in part on the ability of estrogen to decrease production of reactive oxygen species in mitochondria. Mechanisms by which estrogen increases endothelial vasodilator function, promotes angiogenesis, and modulates autonomic function are summarized. Key aspects of the relevant pathophysiology of inflammation, atherosclerosis, stroke, migraine, and thrombosis are reviewed concerning current knowledge of estrogenic effects. A number of emerging concepts are addressed throughout. These include the importance of estrogenic formulation and route of administration and the impact of genetic polymorphisms, either in estrogen receptors or in enzymes responsible for estrogen metabolism, on responsiveness to hormone treatment. The importance of local metabolism of estrogenic precursors and the impact of timing for initiation of treatment and its duration are also considered. Although consensus opinions are emphasized, controversial views are presented to stimulate future research.

Indexed as

AnimalsAtherosclerosisAutonomic Nervous SystemBlood VesselsCardiovascular DiseasesEstrogensHumansInflammationMenopauseMitochondriaNeovascularization, PhysiologicProtein Processing, Post-TranslationalReceptors, AdrenergicReceptors, EstrogenReceptors, G-Protein-CoupledRNA StabilityEstrogensReceptors, AdrenergicReceptors, EstrogenReceptors, G-Protein-CoupledTranscription Factors

Identifiers

PMID18579753
PMCPMC2637768
OpenAlexW2116832131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.