ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Functional remodeling of gap junction-mediated electrical communication between adrenal chromaffin cells in stressed rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 47 citations in OpenAlex.
- Distinct Adrenal Medulla Activity in Germ-Free Versus Conventional Male Rats Under Acute and Chronic Stress.Journal of neurochemistry · 2026Article
- Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner.Frontiers in microbiology · 2025Article
- Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.Cellular and molecular life sciences : CMLS · 2024Article
- Developmental Changes in Gap Junction Expression in Rat Adrenal Medullary Chromaffin Cells.Acta histochemica et cytochemica · 2024Article
- Two firing modes and well-resolved NaPflugers Archiv : European journal of physiology · 2023Article
- Basal and Stress-Induced Network Activity in the Adrenal MedullaFrontiers in endocrinology · 2022Article
- A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ.The Journal of physiology · 2021Article
- The Adrenal Medulla Modulates Mechanical Allodynia in a Rat Model of Neuropathic Pain.International journal of molecular sciences · 2020Article
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.International journal of molecular sciences · 2019Article
- Gap junction communication between chromaffin cells: the hidden face of adrenal stimulus-secretion coupling.Pflugers Archiv : European journal of physiology · 2018Review
- What's New in Endocrinology: The Chromaffin Cell.Frontiers in endocrinology · 2018Review
- Spatially Organized β-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans.Biophysical journal · 2017Article
- Connexin36 localization to pinealocytes in the pineal gland of mouse and rat.The European journal of neuroscience · 2017Article
- Monitoring the Secretory Behavior of the Rat Adrenal Medulla by High-Performance Liquid Chromatography-Based Catecholamine Assay from Slice Supernatants.Frontiers in endocrinology · 2017Article
- Adrenocortical Gap Junctions and Their Functions.Frontiers in endocrinology · 2016Review
- Roles of connexins and pannexins in (neuro)endocrine physiology.Cellular and molecular life sciences : CMLS · 2015Review
- Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability.PLoS computational biology · 2014Article
- Dimensionality and size scaling of coordinated Ca(2+) dynamics in MIN6 β-cell clusters.Biophysical journal · 2014Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increase in circulating catecholamine levels represents one of the mechanisms whereby organisms cope with stress. In the periphery, catecholamines mainly originate from the sympathoadrenal system. As we reported, in addition to the central control through cholinergic innervation, a local gap junction-delineated route between adrenal chromaffin cells contributes to catecholamine exocytosis. Here, we investigated whether this intercellular communication is modified when the hormonal demand is increased as observed during cold stress. Our results show that in cold exposed rats, gap-junctional communication undergoes a functional plasticity, as evidenced by an increased number of dye-coupled cells. Of a physiological interest is that this upregulation of gap-junctional coupling results in the appearance of a robust electrical coupling between chromaffin cells that allows the transmission of action potentials between coupled cells. This enhancement of gap-junctional communication parallels an increase in expression levels of connexin36 (Cx36) and connexin43 (Cx43) proteins. Both transcriptional and posttranslational mechanisms are involved because Cx36 transcripts are increased in stressed rats and the expression of the scaffolding protein zonula occludens-1, known to interact with both Cx36 and Cx43, is also upregulated. Consistent with an upregulated coupling extent in stressed rats, the cytosolic Ca(2+) concentration rises triggered in a single cell by an iontophoretic application of nicotine occur simultaneously in several neighboring cells. These results describe for the first time a functional plasticity of junctional coupling between adult chromaffin cells that should be crucial for adaptation to stress or sensitization to subsequent stressors.
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