ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
In vivo calcium imaging reveals functional rewiring of single somatosensory neurons after stroke.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 174 citations in OpenAlex.
- Escitalopram promotes recovery from hand paresis in cortical sensori-motor stroke: a randomized, double-blind, placebo-controlled longitudinal study.Journal of neuroengineering and rehabilitation · 2026Trial
- The effect of a single dose of escitalopram on sensorimotor networks.Brain and behavior · 2018Trial
- Prolonged perceptual learning of positional acuity in adult amblyopia: perceptual template retuning dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Trial
- Constructing mesoscale functionomics by neural dynamics subspace clustering.National science review · 2026Article
- Signatures of Covert Neuron Loss in the Local Field Potential of Motor Cortex.Journal of the American Heart Association · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025Review
- Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice.Neurophotonics · 2025Article
- Article
- Astrocyte Regulation of Neuronal Function and Survival in Stroke Pathophysiology.Advances in neurobiology · 2024Review
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Sex differences in the mouse photothrombotic stroke model investigated with X-ray fluorescence microscopy and Fourier transform infrared spectroscopic imaging.IBRO neuroscience reports · 2022Article
- Multimodal imaging of hemorrhagic transformation biomarkers in an ischemic stroke model.Metallomics : integrated biometal science · 2022Article
- Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice.Journal of biomedical optics · 2022Article
- Two-photon calcium imaging of neuronal activity.Nature reviews. Methods primers · 2022Article
- Poststroke dendritic arbor regrowth requires the actin nucleator Cobl.PLoS biology · 2021Article
- Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy.Nature communications · 2021Article
- Glial Cell Line-Derived Neurotrophic Factor and Focal Ischemic Stroke.Neurochemical research · 2021Review
- Cellular-resolution monitoring of ischemic stroke pathologies in the rat cortex.Biomedical optics express · 2021Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional mapping and microstimulation studies suggest that recovery after stroke damage can be attributed to surviving brain regions taking on the functional roles of lost tissues. Although this model is well supported by data, it is not clear how activity in single neurons is altered in relation to cortical functional maps. It is conceivable that individual surviving neurons could adopt new roles at the expense of their usual function. Alternatively, neurons that contribute to recovery may take on multiple functions and exhibit a wider repertoire of neuronal processing. In vivo two-photon calcium imaging was used in adult mice within reorganized forelimb and hindlimb somatosensory functional maps to determine how the response properties of individual neurons and glia were altered during recovery from ischemic damage over a period of 2-8 weeks. Single-cell calcium imaging revealed that the limb selectivity of individual neurons was altered during recovery from ischemia, such that neurons normally selective for a single contralateral limb processed information from multiple limbs. Altered limb selectivity was most prominent in border regions between stroke-altered forelimb and hindlimb macroscopic map representations, and peaked 1 month after the targeted insult. Two months after stroke, individual neurons near the center of reorganized functional areas became more selective for a preferred limb. These previously unreported forms of plasticity indicate that in adult animals, seemingly hardwired cortical neurons first adopt wider functional roles as they develop strategies to compensate for loss of specific sensory modalities after forms of brain damage such as stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.