ArticleClinical and vaccine immunology : CVI2008
Interleukin-23 is required for development of arthritis in mice vaccinated and challenged with Borrelia species.
Article in Clinical and vaccine immunology : CVI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Aspects of the Immunopathogenesis of Lyme Arthritis.Microorganisms · 2025Review
- Monocyte dysregulation: consequences for hepatic infections.Seminars in immunopathology · 2021Review
- T-Helper 17 Cell Cytokine Responses in Lyme Disease Correlate With Borrelia burgdorferi Antibodies During Early Infection and With Autoantibodies Late in the Illness in Patients With Antibiotic-Refractory Lyme Arthritis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Immunization with Bivalent Flagellin Protects Mice against FatalJournal of immunology research · 2017Article
- Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi.Journal of leukocyte biology · 2016Article
- Infection of Interleukin 17 Receptor A-Deficient C3H Mice with Borrelia burgdorferi Does Not Affect Their Development of Lyme Arthritis and Carditis.Infection and immunity · 2015Article
- Elevated levels of IL-23 in a subset of patients with post-lyme disease symptoms following erythema migrans.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
- Interleukin-10 (IL-10) inhibits Borrelia burgdorferi-induced IL-17 production and attenuates IL-17-mediated Lyme arthritis.Infection and immunity · 2013Article
- Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease.Infection and immunity · 2011Article
- Interleukin-35 enhances Lyme arthritis in Borrelia-vaccinated and -infected mice.Clinical and vaccine immunology : CVI · 2011Article
- Indications of Th1 and Th17 responses in cerebrospinal fluid from patients with Lyme neuroborreliosis: a large retrospective study.Journal of neuroinflammation · 2011Article
- Th17 cytokines and arthritis.Seminars in immunopathology · 2010Review
- The role of T helper type 17 cells in inflammatory arthritis.Clinical and experimental immunology · 2010Review
- Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens.Immunology · 2009Review
- CD28 co-stimulation down regulates Th17 development.PloS one · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently hypothesized that T helper 17 (Th17) cells and their associated cytokines are involved in the development of arthritis following infection with Borrelia burgdorferi. Here, we show that interleukin-23 (IL-23), a survival factor for Th17 cells, is required for the induction of arthritis in mice vaccinated with B. burgdorferi strain 297 and challenged with "Borrelia bissettii." When Borrelia-vaccinated and -challenged mice were given antibodies to the p19 subunit of IL-23, they failed to develop the histopathological changes observed in untreated vaccinated and challenged mice. In addition, viable B. bissettii organisms stimulated the secretion of IL-17 from Borrelia-immune lymph node cells during in vitro culture. When anti-IL-23 p19 antibody was included in cultures of B. bissettii organisms and Borrelia-immune lymph node cells, the production of IL-17 was reduced to levels observed in cultures containing immune cells alone. Taken together, these results support the hypothesis that Th17 cell-associated cytokines are involved in the development of Borrelia-mediated arthritis. These findings provide insight into previously overlooked immune mechanisms responsible for the development of Lyme arthritis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.