ArticleMolecular biology of the cell2008
Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 63 citations in OpenAlex.
- On the origin of the nucleus: a hypothesis.Microbiology and molecular biology reviews : MMBR · 2023Review
- Adhesion and Polarity protein distribution-regulates hexagon dominated plasma membrane organization in Drosophila blastoderm embryos.Genetics · 2023Article
- Early zygotic gene product Dunk interacts with anillin to regulate Myosin II duringMolecular biology of the cell · 2023Article
- β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila.Developmental biology · 2023Article
- Diversity is the spice of life: An overview of how cytokinesis regulation varies with cell type.Frontiers in cell and developmental biology · 2022Review
- Complementary functions for the Ran gradient during division.Small GTPases · 2021Review
- Review
- Importin binding mediates the intramolecular regulation of anillin during cytokinesis.Molecular biology of the cell · 2020Article
- Animal Cell Cytokinesis: The Rho-Dependent Actomyosin-Anilloseptin Contractile Ring as a Membrane Microdomain Gathering, Compressing, and Sorting Machine.Frontiers in cell and developmental biology · 2020Article
- The Unusual Suspects in Cytokinesis: Fitting the Pieces Together.Frontiers in cell and developmental biology · 2020Review
- Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network.eLife · 2019Article
- Transfection of choanoflagellates illuminates their cell biology and the ancestry of animal septins.Molecular biology of the cell · 2018Article
- The ABD on the nascent polypeptide and PH domain are required for the precise Anillin localization in Drosophila syncytial blastoderm.Scientific reports · 2018Article
- The anillin-related Int1 protein and the Sep7 septin collaborate to maintain cellular ploidy in Candida albicans.Scientific reports · 2018Article
- Active Ran regulates anillin function during cytokinesis.Molecular biology of the cell · 2017Article
- Coupling changes in cell shape to chromosome segregation.Nature reviews. Molecular cell biology · 2016Review
- Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5.G3 (Bethesda, Md.) · 2016Article
- Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial Drosophila embryo.Molecular biology of the cell · 2016Article
- Store-independent modulation of Ca(2+) entry through Orai by Septin 7.Nature communications · 2016Article
- The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.Oncotarget · 2015Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
During early development in Drosophila, pseudocleavage furrows in the syncytial embryo prevent contact between neighboring spindles, thereby ensuring proper chromosome segregation. Here we demonstrate that the GTPase Ran regulates pseudocleavage furrow organization. Ran can exert control on pseudocleavage furrows independently of its role in regulating the microtubule cytoskeleton. Disruption of the Ran pathway prevented pseudocleavage furrow formation and restricted the depth and duration of furrow ingression of those pseudocleavage furrows that did form. We found that Ran was required for the localization of the septin Peanut to the pseudocleavage furrow, but not anillin or actin. Biochemical assays revealed that the direct binding of the nuclear transport receptors importin alpha and beta to anillin prevented the binding of Peanut to anillin. Furthermore, RanGTP reversed the inhibitory action of importin alpha and beta. On expression of a mutant form of anillin that lacked an importin alpha and beta binding site, inhibition of Ran no longer restricted the depth and duration of furrow ingression in those pseudocleavage furrows that formed. These data suggest that anillin and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos and that this process is regulated by Ran.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.