ArticleMolecular biology of the cell2008
Three members of the LC8/DYNLL family are required for outer arm dynein motor function.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Phyloproteomics reveals conserved patterns of axonemal dynein methylation across the motile ciliated eukaryotes.Molecular biology of the cell · 2025Article
- Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.Journal of molecular cell biology · 2019Article
- Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP.The Journal of cell biology · 2018Article
- Reduced tubulin polyglutamylation suppresses flagellar shortness in Chlamydomonas.Molecular biology of the cell · 2015Article
- Recent advances in primary ciliary dyskinesia genetics.Journal of medical genetics · 2015Review
- Article
- Protein-protein interactions between intermediate chains and the docking complex of Chlamydomonas flagellar outer arm dynein.FEBS letters · 2013Article
- Association of Lis1 with outer arm dynein is modulated in response to alterations in flagellar motility.Molecular biology of the cell · 2012Article
- Integrated control of axonemal dynein AAA(+) motors.Journal of structural biology · 2012Review
- Article
- Ordered deployment of distinct ciliary beating machines in growing axonemes of vertebrate multiciliated cells.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The highly conserved LC8/DYNLL family proteins were originally identified in axonemal dyneins and subsequently found to function in multiple enzyme systems. Genomic analysis uncovered a third member (LC10) of this protein class in Chlamydomonas. The LC10 protein is extracted from flagellar axonemes with 0.6 M NaCl and cofractionates with the outer dynein arm in sucrose density gradients. Furthermore, LC10 is specifically missing only from axonemes of those strains that fail to assemble outer dynein arms. Previously, the oda12-1 insertional allele was shown to lack the Tctex2-related dynein light chain LC2. The LC10 gene is located approximately 2 kb from that of LC2 and is also completely missing from this mutant but not from oda12-2, which lacks only the 3' end of the LC2 gene. Although oda12-1 cells assemble outer arms that lack only LC2 and LC10, this strain exhibits a flagellar beat frequency that is consistently less than that observed for strains that fail to assemble the entire outer arm and docking complex (e.g., oda1). These results support a key regulatory role for the intermediate chain/light chain complex that is an integral and highly conserved feature of all oligomeric dynein motors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.