ArticleJournal of neurophysiology2008
Using a model to assess the role of the spatiotemporal pattern of inhibitory input and intrasegmental electrical coupling in the intersegmental and side-to-side coordination of motor neurons by the leech heartbeat central pattern generator.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Comodulation of h- and NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The neural control of heartbeat in invertebrates.Current opinion in neurobiology · 2016Review
- Mechanisms of coordination in distributed neural circuits: decoding and integration of coordinating information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation.PloS one · 2013Article
- Centrally patterned rhythmic activity integrated by a peripheral circuit linking multiple oscillators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Small is beautiful: models of small neuronal networks.Current opinion in neurobiology · 2012Review
- Coping with variability in small neuronal networks.Integrative and comparative biology · 2011Review
- Patterns of presynaptic activity and synaptic strength interact to produce motor output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Bringing up the rear: new premotor interneurons add regional complexity to a segmentally distributed motor pattern.Journal of neurophysiology · 2011Article
- Contribution of motoneuron intrinsic properties to fictive motor pattern generation.Journal of neurophysiology · 2011Article
- Constancy and variability in the output of a central pattern generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A role for compromise: synaptic inhibition and electrical coupling interact to control phasing in the leech heartbeat CpG.Frontiers in behavioral neuroscience · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Previously we presented a quantitative description of the spatiotemporal pattern of inhibitory synaptic input from the heartbeat central pattern generator (CPG) to segmental motor neurons that drive heartbeat in the medicinal leech and the resultant coordination of CPG interneurons and motor neurons. To begin elucidating the mechanisms of coordination, we explore intersegmental and side-to-side coordination in an ensemble model of all heart motor neurons and their known synaptic inputs and electrical coupling. Model motor neuron intrinsic properties were kept simple, enabling us to determine the extent to which input and electrical coupling acting together can account for observed coordination in the living system in the absence of a substantive contribution from the motor neurons themselves. The living system produces an asymmetric motor pattern: motor neurons on one side fire nearly in synchrony (synchronous), whereas on the other they fire in a rear-to-front progression (peristaltic). The model reproduces the general trends of intersegmental and side-to-side phase relations among motor neurons, but the match with the living system is not quantitatively accurate. Thus realistic (experimentally determined) inputs do not produce similarly realistic output in our model, suggesting that motor neuron intrinsic properties may contribute to their coordination. By varying parameters that determine electrical coupling, conduction delays, intraburst synaptic plasticity, and motor neuron excitability, we show that the most important determinant of intersegmental and side-to-side phase relations in the model was the spatiotemporal pattern of synaptic inputs, although phasing was influenced significantly by electrical coupling.
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