ArticleJournal of virology2008
Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Global landscape of coxsackieviruses in human health.Virus research · 2024Review
- Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred.BMC infectious diseases · 2022Article
- Review
- Genetic landscape and macro-evolution of co-circulating Coxsackieviruses A and Vaccine-derived Polioviruses in the Democratic Republic of Congo, 2008-2013.PLoS neglected tropical diseases · 2019Article
- Deep sequencing prompts the modification of a real-time RT-PCR for the serotype-specific detection of polioviruses.Journal of virological methods · 2019Article
- Whole Genome Sequencing of Enteroviruses Species A to D by High-Throughput Sequencing: Application for Viral Mixtures.Frontiers in microbiology · 2018Article
- Detection of Emerging Vaccine-Related Polioviruses by Deep Sequencing.Journal of clinical microbiology · 2017Article
- Invasions of Host-Associated Microbiome Networks.Advances in ecological research · 2017Article
- Exchanges of genomic domains between poliovirus and other cocirculating species C enteroviruses reveal a high degree of plasticity.Scientific reports · 2016Article
- Recombination among human non-polio enteroviruses: implications for epidemiology and evolution.Virus genes · 2015Review
- Precise genotyping and recombination detection of Enterovirus.BMC genomics · 2015Article
- Evolution and Emergence of Enteroviruses through Intra- and Inter-species Recombination: Plasticity and Phenotypic Impact of Modular Genetic Exchanges in the 5' Untranslated Region.PLoS pathogens · 2015Article
- Article
- The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication.Journal of virology · 2013Article
- Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses.Journal of virology · 2012Article
- Recombination between poliovirus and coxsackie A viruses of species C: a model of viral genetic plasticity and emergence.Viruses · 2011Review
- Recombination between polioviruses and co-circulating Coxsackie A viruses: role in the emergence of pathogenic vaccine-derived polioviruses.PLoS pathogens · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.