ArticleThe Journal of biological chemistry2008
Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Mechanical regulation of lymphocyte activation and function.Journal of cell science · 2024Review
- Role of MHC class I pathways inFrontiers in cellular and infection microbiology · 2023Review
- Mechanosurveillance: Tiptoeing T Cells.Frontiers in immunology · 2022Review
- The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cytokines Induce Faster Membrane Diffusion of MHC Class I and the Ly49A Receptor in a Subpopulation of Natural Killer Cells.Frontiers in immunology · 2016Article
- Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner.The Journal of biological chemistry · 2015Article
- Ligand-mediated friction determines morphodynamics of spreading T cells.Biophysical journal · 2014Article
- Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling.PloS one · 2012Article
- Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research.Frontiers in immunology · 2012Article
- Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes.Immunologic research · 2011Review
- Analysis of molecular diffusion by first-passage time variance identifies the size of confinement zones.Biophysical journal · 2011Article
- Direct observation and quantitative analysis of Lck exchange between plasma membrane and cytosol in living T cells.The Journal of biological chemistry · 2010Article
- Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.Immunity · 2010Article
- Co-receptors and recognition of self at the immunological synapse.Current topics in microbiology and immunology · 2010Review
- A role for rebinding in rapid and reliable T cell responses to antigen.PLoS computational biology · 2009Article
- Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins.Biotechnology journal · 2009Review
- The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- MHC molecules lead many lives. Workshop on MHC Class I Molecules at the interface between Biology & Medicine.EMBO reports · 2009Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD8(+) cytotoxic T lymphocytes (CTL) can recognize and kill target cells expressing only a few cognate major histocompatibility complex (MHC) I-peptide complexes. This high sensitivity requires efficient scanning of a vast number of highly diverse MHC I-peptide complexes by the T cell receptor in the contact site of transient conjugates formed mainly by nonspecific interactions of ICAM-1 and LFA-1. Tracking of single H-2K(d) molecules loaded with fluorescent peptides on target cells and nascent conjugates with CTL showed dynamic transitions between states of free diffusion and immobility. The immobilizations were explained by association of MHC I-peptide complexes with ICAM-1 and strongly increased their local concentration in cell adhesion sites and hence their scanning by T cell receptor. In nascent immunological synapses cognate complexes became immobile, whereas noncognate ones diffused out again. Interfering with this mobility modulation-based concentration and sorting of MHC I-peptide complexes strongly impaired the sensitivity of antigen recognition by CTL, demonstrating that it constitutes a new basic aspect of antigen presentation by MHC I molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.