ArticleGenetics2008
Cytotype regulation of P transposable elements in Drosophila melanogaster: repressor polypeptides or piRNAs?
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Host-transposable element coexistence: a matter of resistance, tolerance and trade-off.The EMBO journal · 2026Review
- Rapid evolution of piRNA-mediated silencing of an invading transposable element was driven by abundant de novo mutations.Genome research · 2020Article
- Paternal Induction of Hybrid Dysgenesis inG3 (Bethesda, Md.) · 2017Article
- Reexamining the P-Element Invasion of Drosophila melanogaster Through the Lens of piRNA Silencing.Genetics · 2016Review
- Cytotype Regulation Facilitates Repression of Hybrid Dysgenesis by Naturally Occurring KP Elements in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- The cellular basis of hybrid dysgenesis and Stellate regulation in Drosophila.Current opinion in genetics & development · 2015Review
- Transposon regulation in Drosophila: piRNA-producing P elements facilitate repression of hybrid dysgenesis by a P element that encodes a repressor polypeptide.Molecular genetics and genomics : MGG · 2015Article
- Genetic interactions between P elements involved in piRNA-mediated repression of hybrid dysgenesis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- A test for enhancement of cytotype regulation in Drosophila melanogaster by the transposase-encoding P element ∆2-3.Molecular genetics and genomics : MGG · 2013Article
- IPB7 transposase behavior in Drosophila melanogaster and Aedes aegypti.Insect biochemistry and molecular biology · 2013Article
- Article
- The mosquito Aedes aegypti has a large genome size and high transposable element load but contains a low proportion of transposon-specific piRNAs.BMC genomics · 2011Article
- Point mutations in a Drosophila P element abolish both P element-dependent silencing (PDS) of a transgene and repressor functions.Chromosoma · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The telomeric P elements TP5 and TP6 are associated with the P cytotype, a maternally inherited condition that represses P-element-induced hybrid dysgenesis in the Drosophila germ line. To see if cytotype repression by TP5 and TP6 might be mediated by the polypeptides they could encode, hobo transgenes carrying these elements were tested for expression of mRNA in the female germ line and for repression of hybrid dysgenesis. The TP5 and TP6 transgenes expressed more germ-line mRNA than the native telomeric P elements, but they were decidedly inferior to the native elements in their ability to repress hybrid dysgenesis. These paradoxical results are inconsistent with the repressor polypeptide model of cytotype. An alternative model based on the destruction of P transposase mRNA by Piwi-interacting (pi) RNAs was supported by finding reduced P mRNA levels in flies that carried the native telomeric P elements, which are inserted in a known major piRNA locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.