ArticleAlcohol (Fayetteville, N.Y.)2008
Wheel running, voluntary ethanol consumption, and hedonic substitution.
Article in Alcohol (Fayetteville, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Transcriptome Analysis of Hippocampus After Weekly Binge Alcohol Exposure and Voluntary Exercise in Rats.Alcohol, clinical & experimental research · 2026Article
- Exercise (Wheel-Running) Reduces Chronic Alcohol-Induced Escalation of Drinking in Mice via Elevated BDNF-TrkB Receptor Activity.Research square · 2026Article
- Utility of substance-free alternatives in treating and preventing harmful substance use: A narrative review of the translational research spectrum.Drug and alcohol dependence reports · 2025Review
- Voluntary wheel-running reduces harmful drinking in a genetic risk model for drinking to intoxication.Alcohol (Fayetteville, N.Y.) · 2025Article
- Editorial: The role, and underlying neural mechanisms of, physical activity in treating substance and alcohol use disorders.Frontiers in integrative neuroscience · 2025Article
- Effects of chronic alcohol intoxication on aerobic exercise-induced adaptations in female mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free-choice ethanol drinking but not binge-like drinking or wheel-running activity.Alcohol, clinical & experimental research · 2023Article
- The impact of intermittent exercise on mouse ethanol drinking and abstinence-associated affective behavior and physiology.Alcoholism, clinical and experimental research · 2022Article
- The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats.Frontiers in behavioral neuroscience · 2022Article
- Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex.Brain, behavior, and immunity · 2016Article
- Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling.Genes, brain, and behavior · 2016Article
- Exercise training - A beneficial intervention in the treatment of alcohol use disorders?Drug and alcohol dependence · 2016Review
- What can be learnt from wheel-running by wild mice, and how can we identify when wheel-running is pathological?Proceedings. Biological sciences · 2016Article
- Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches.Alcohol (Fayetteville, N.Y.) · 2015Review
- Exercise and Alcohol Consumption: What We Know, What We Need to Know, and Why it is Important.Frontiers in psychiatry · 2015Review
- Voluntary exercise decreases ethanol preference and consumption in C57BL/6 adolescent mice: sex differences and hippocampal BDNF expression.Physiology & behavior · 2015Article
- Increased adult hippocampal neurogenesis is not necessary for wheel running to abolish conditioned place preference for cocaine in mice.The European journal of neuroscience · 2015Article
- Circadian activity rhythms and voluntary ethanol intake in male and female ethanol-preferring rats: effects of long-term ethanol access.Alcohol (Fayetteville, N.Y.) · 2014Article
- Oral self-administration of EtOH: sex-dependent modulation by running wheel access in C57BL/6J mice.Alcoholism, clinical and experimental research · 2014Article
- Mesolimbic transcriptional response to hedonic substitution of voluntary exercise and voluntary ethanol consumption.Behavioural brain research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Few studies have examined the relationship between naturally rewarding behaviors and ethanol drinking behaviors in mice. Although natural and drug reinforcers activate similar brain circuitry, there is behavioral evidence suggesting food and drug rewards differ in perceived value. The primary goal of the present study was to investigate the relationships between naturally reinforcing stimuli and consumption of ethanol in ethanol preferring C57BL/6J mice. Mouse behaviors were observed after the following environmental manipulations: standard or enhanced environment, accessible or inaccessible wheel, and presence or absence of ethanol. Using a high-resolution volumetric drinking monitor and wheel running monitor, we evaluated whether alternating access to wheel running modified ethanol-related behaviors and whether alternating access to ethanol modified wheel running or subsequent ethanol-related behaviors. We found that ethanol consumption remains stable with alternating periods of wheel running. Wheel running increases in the absence of ethanol and decreases upon reintroduction of ethanol. Upon reintroduction of ethanol, an alcohol deprivation effect was seen. Collectively, the results support theories of hedonic substitution and suggest that female C57BL/6J mice express ethanol seeking and craving under these specific conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.