ArticleCurrent treatment options in neurology2008
Human T-lymphotropic virus 1 neurologic disease.
Article in Current treatment options in neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Article
- Acute myelitis as presenting symptom of HIV-HTLV-1 co-infection.Journal of neurovirology · 2016Article
- Nation-wide epidemiological study of Japanese patients with rare viral myelopathy using novel registration system (HAM-net).Orphanet journal of rare diseases · 2016Article
- Update on Neurological Manifestations of HTLV-1 Infection.Current infectious disease reports · 2015Article
- A Caucasian Australian presenting with human T-lymphotropic virus type I associated myelopathy: a case report.Journal of medical case reports · 2014Article
- [HTLV-1-associated myelopathy/tropical spastic paraparesis: a differential diagnosis in multiple sclerosis].Der Nervenarzt · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human T-lymphotrophic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a disabling myelopathy, but clinical trials of specific drugs to treat it are lacking. There are many reasons for the absence of specific therapeutic studies, including difficulty in enrolling patients, inadequate measurement tools to evaluate neurologic improvement, and even lack of interest. Oral or intravenous corticosteroids are now the mainstay of HAM/TSP treatment, especially in the initial phase of the disease, when inflammation is more prominent than demyelination. Motor disability, pain, and urinary dysfunction may be ameliorated, but improvement is not sustained in many patients. Valproic acid has emerged as a potential treatment for HAM/TSP; recent evidence shows that this drug can activate viral gene expression and expose virus-infected cells to the immune system, leading to a reduction of the proviral load. Alternative drugs such as methotrexate, pentoxifylline, azathioprine, danazol, and interferon-alpha may be used if steroids fail or cannot be tolerated, but they have not been assessed in randomized clinical trials.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.